{"id":"7ef0b4a2-c9f5-5b92-8386-4d787a256ddd","stable_key":"6d38d43e-01e4-5641-93be-65654271e242:zinc-trans-zip5-diet-deficiency","predicate":"deficiency_reduces","statement":"During dietary zinc deficiency in mice, ZIP5 protein was internalized and degraded in enterocytes, pancreatic acinar cells and visceral endoderm even though Zip5 mRNA abundance did not change.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"2bbb3ac5-a265-5f82-bab8-8ab1f9af1318","mechanism_event_label":"Zinc deficiency reduced ZIP5 protein without reducing its messenger RNA.","subject":{"id":"0429f0ff-c033-514b-9a4f-6f0f83268095","slug":"zinc","display_name":"Zinc","entity_type_key":"nutrient_element"},"object":{"id":"45158ac2-5824-52bb-8342-bc23628c902f","slug":"zip5-protein-abundance","display_name":"ZIP5 protein abundance","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"2bbb3ac5-a265-5f82-bab8-8ab1f9af1318","stable_key":"6d38d43e-01e4-5641-93be-65654271e242:zinc-trans-zip5-diet-deficiency-event","event_type":"biochemical_relationship","label":"Zinc deficiency reduced ZIP5 protein without reducing its messenger RNA.","description":"During dietary zinc deficiency in mice, ZIP5 protein was internalized and degraded in enterocytes, pancreatic acinar cells and visceral endoderm even though Zip5 mRNA abundance did not change.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"5d71153b-6474-5bc7-89ff-666b940683da","slug":"mouse-slc39a5","display_name":"Mouse ZIP5 (Slc39a5)","entity_type_key":"protein"},"role":"regulated_transporter","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"0429f0ff-c033-514b-9a4f-6f0f83268095","slug":"zinc","display_name":"Zinc","entity_type_key":"nutrient_element"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"45158ac2-5824-52bb-8342-bc23628c902f","slug":"zip5-protein-abundance","display_name":"ZIP5 protein abundance","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"cross_nutrient","value_text":"false","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Dietary depletion/repletion and protein/RNA assays","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Defined zinc-deficient diet followed in some experiments by oral zinc repletion.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Protein abundance, transcription and transport flux are different endpoints; this is a mouse dietary adaptation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Zinc research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"zinc","display_name":"Zinc","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Mus musculus","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Zinc deficiency reduced ZIP5 protein without reducing its messenger RNA.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[zinc-trans-18020946] Novel zinc-responsive post-transcriptional mechanisms reciprocally regulate expression of the mouse Slc39a4 and Slc39a5 zinc transporters (Zip4 and Zip5). (2007). https://pubmed.ncbi.nlm.nih.gov/18020946/ DOI: 10.1515/bc.2007.149","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Enterocytes, acinar cells and visceral endoderm","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"84b4d778-4cf7-556b-b43b-5394a6775b71","evidence_kind":"source_excerpt","locator":"Lines 414-425","start_line":414,"end_line":425,"excerpt":"### zinc-trans-zip5-diet-deficiency\nDuring dietary zinc deficiency in mice, ZIP5 protein was internalized and degraded in enterocytes, pancreatic acinar cells and visceral endoderm even though Zip5 mRNA abundance did not change.\nCondition category: nutrient_deficiency\nnutrient_topic: Zinc research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Zinc deficiency reduced ZIP5 protein without reducing its messenger RNA.\norganism: Mus musculus\ntissue_or_cell_type: Enterocytes, acinar cells and visceral endoderm\nexperimental_model: Dietary depletion/repletion and protein/RNA assays\nlimitations: Protein abundance, transcription and transport flux are different endpoints; this is a mouse dietary adaptation.\nexposure: Defined zinc-deficient diet followed in some experiments by oral zinc repletion.\ncross_nutrient: false\n[zinc-trans-18020946] Novel zinc-responsive post-transcriptional mechanisms reciprocally regulate expression of the mouse Slc39a4 and Slc39a5 zinc transporters (Zip4 and Zip5). (2007). https://pubmed.ncbi.nlm.nih.gov/18020946/ DOI: 10.1515/bc.2007.149","model_system":"Dietary depletion/repletion and protein/RNA assays","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [zinc-trans-18020946] Novel zinc-responsive post-transcriptional mechanisms reciprocally regulate expression of the mouse Slc39a4 and Slc39a5 zinc transporters (Zip4 and Zip5). (2007). https://pubmed.ncbi.nlm.nih.gov/18020946/ DOI: 10.1515/bc.2007.149","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"c5ee0fee-ce5c-58de-905a-10fb0ea0723c","stable_key":"import-6d38d43e-01e4-5641-93be-65654271e242","title":"Zinc: transport, enzyme loading, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. 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