{"id":"7eeadd9c-c32c-55a0-b248-bf145feead37","stable_key":"aaa7baba-8689-56ab-ba1e-b71542bcb8e9:iod-clin-albania-thyroxine","predicate":"repletion-increases","statement":"At 24 weeks, mean total T4 in iodine-treated children was approximately 40% higher than baseline and hypothyroxinemia prevalence was below 1%; corresponding placebo-group status did not improve significantly.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"45132621-f781-5746-ab4f-eb902ded805b","mechanism_event_label":"Iodine repletion restored thyroid hormone status in these moderately deficient children.","subject":{"id":"a6c8a491-944e-5f9a-9caf-6e9063b9030f","slug":"iodized-oil","display_name":"Iodized oil preparation","entity_type_key":"chemical_species"},"object":{"id":"90c33fc7-1fee-5949-a863-a7848a22123f","slug":"serum-total-t4-concentration","display_name":"Serum total thyroxine concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"45132621-f781-5746-ab4f-eb902ded805b","stable_key":"aaa7baba-8689-56ab-ba1e-b71542bcb8e9:iod-clin-albania-thyroxine-event","event_type":"observed_intervention","label":"Iodine repletion restored thyroid hormone status in these moderately deficient children.","description":"At 24 weeks, mean total T4 in iodine-treated children was approximately 40% higher than baseline and hypothyroxinemia prevalence was below 1%; corresponding placebo-group status did not improve significantly.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"0e0ac6d1-3336-506a-9f69-5838ca1500ed","slug":"iodine","display_name":"Iodine","entity_type_key":"nutrient_element"},"role":"repleted nutrient","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"f2b25f38-ec94-57d0-a46d-dd0fee45f01e","slug":"thyroxine","display_name":"T4","entity_type_key":"small_molecule"},"role":"measured hormone","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"240520a5-5777-5f4f-aa45-1dfca6abc55d","slug":"urinary-iodine-concentration","display_name":"Urinary iodine concentration","entity_type_key":"cellular_process"},"role":"status measurement","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"a6c8a491-944e-5f9a-9caf-6e9063b9030f","slug":"iodized-oil","display_name":"Iodized oil preparation","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"90c33fc7-1fee-5949-a863-a7848a22123f","slug":"serum-total-t4-concentration","display_name":"Serum total thyroxine concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"cross_nutrient","value_text":"false","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_location","value_text":"Primary full PDF Methods, Results, Tables 1–2 and Discussion, pp.108–114.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Randomized double-blind placebo-controlled 24-week trial in 310 moderately iodine-deficient Albanian children aged 10–12","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"One supervised oral dose of iodized poppyseed oil containing 400 mg iodine versus sunflower-oil placebo; baseline median urinary iodine 43 micrograms/L, 87% goitrous; iodine 159/placebo 151 randomized.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Baseline groups differed on four psychological tests; analyses adjusted for baseline score, school and sex. Follow-up was 24 weeks, with no proof of lasting IQ or school-performance improvement. Symbol-search test-retest reliability was modest. Dose is a historical depot intervention, not daily intake. The 40% figure is a within-treatment change described in the abstract, not a verified adjusted between-group estimate.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Iodine research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"iodine","display_name":"Iodine","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Iodine repletion restored thyroid hormone status in these moderately deficient children.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[iod-clin-albania2006] Iodine supplementation improves cognition in iodine-deficient schoolchildren in Albania: a randomized, controlled, double-blind study. 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Follow-up was 24 weeks, with no proof of lasting IQ or school-performance improvement. Symbol-search test-retest reliability was modest. Dose is a historical depot intervention, not daily intake. The 40% figure is a within-treatment change described in the abstract, not a verified adjusted between-group estimate.\nexposure: One supervised oral dose of iodized poppyseed oil containing 400 mg iodine versus sunflower-oil placebo; baseline median urinary iodine 43 micrograms/L, 87% goitrous; iodine 159/placebo 151 randomized.\ncross_nutrient: false\nevidence_location: Primary full PDF Methods, Results, Tables 1–2 and Discussion, pp.108–114.\n[iod-clin-albania2006] Iodine supplementation improves cognition in iodine-deficient schoolchildren in Albania: a randomized, controlled, double-blind study. 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