{"id":"7ece0bf1-004d-5d07-b262-e6e887d5c2d6","stable_key":"22527305-af1f-536a-b419-7e73f08cc3ec:luteolin-copper-binding","predicate":"complexes","statement":"Spectroscopy assigned Cu(II) coordination by luteolin to the 5-hydroxyl/4-carbonyl region.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"2d691030-ea4c-52d1-abc5-9722997f3c4a","mechanism_event_label":"Copper need not bind at the same site assigned for iron.","subject":{"id":"80472c4b-ecc2-52e3-a766-f8463294774f","slug":"luteolin","display_name":"Luteolin / 3′,4′,5,7-tetrahydroxyflavone","entity_type_key":"small_molecule"},"object":{"id":"2a870bb5-05a0-5e51-a70c-a9a843a8b571","slug":"copper-ii","display_name":"Copper(II) ion","entity_type_key":"ion"},"evidence_count":1,"mechanism_event":{"id":"2d691030-ea4c-52d1-abc5-9722997f3c4a","stable_key":"22527305-af1f-536a-b419-7e73f08cc3ec:luteolin-copper-binding-event","event_type":"observed_relationship","label":"Copper need not bind at the same site assigned for iron.","description":"Spectroscopy assigned Cu(II) coordination by luteolin to the 5-hydroxyl/4-carbonyl region.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"80472c4b-ecc2-52e3-a766-f8463294774f","slug":"luteolin","display_name":"Luteolin / 3′,4′,5,7-tetrahydroxyflavone","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"2a870bb5-05a0-5e51-a70c-a9a843a8b571","slug":"copper-ii","display_name":"Copper(II) ion","entity_type_key":"ion"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Cell-free Cu(II) spectroscopy.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Metal, pH and preparation matter; no human copper-balance measurement.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Luteolin collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"luteolin","display_name":"Luteolin / 3′,4′,5,7-tetrahydroxyflavone","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Copper need not bind at the same site assigned for iron.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"The effect of Luteolin on DNA damage mediated by a copper catalyzed Fenton reaction. · 2022 · https://pubmed.ncbi.nlm.nih.gov/34717250/ · DOI 10.1016/j.jinorgbio.2021.111635","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"1eeef3d1-cdc6-53ef-8fca-b950c0b82ff8","evidence_kind":"source_excerpt","locator":"Lines 316-322","start_line":316,"end_line":322,"excerpt":"## luteolin-copper-binding\nCopper need not bind at the same site assigned for iron.\nSpectroscopy assigned Cu(II) coordination by luteolin to the 5-hydroxyl/4-carbonyl region.\nModel: Cell-free Cu(II) spectroscopy.\nLimitations: Metal, pH and preparation matter; no human copper-balance measurement.\nEvidence access: Primary abstract\nThe effect of Luteolin on DNA damage mediated by a copper catalyzed Fenton reaction. · 2022 · https://pubmed.ncbi.nlm.nih.gov/34717250/ · DOI 10.1016/j.jinorgbio.2021.111635","model_system":"Cell-free Cu(II) spectroscopy.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"26337a08-5cee-5cee-900e-e6d3e26ac6e4","stable_key":"import-22527305-af1f-536a-b419-7e73f08cc3ec","title":"Luteolin: metabolism, immune signaling, redox chemistry and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"fd6ea0b1cef8d1c9965270494bfa815de14f679044f0b5d5d7bbf4904630ad76","revision_id":"c9a3dd80-c7e6-5fb4-bc91-8db265e7c8de","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}