{"id":"7e642c1c-2257-5a73-908c-90f7ae996347","stable_key":"ee4227e5-80d7-55e9-ada7-3c5a16f93ac9:cla-human-nitro-9","predicate":"coadministration_increases","statement":"Adding CLA during labeled oral nitrite administration increased plasma 9-nitro-CLA formation.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"66cdc1bb-2d5c-537d-8bed-1c701785c670","mechanism_event_label":"Dietary lipid changed which nitrogen-oxide products formed.","subject":{"id":"6f0cf7bd-c6e5-52d1-92f8-dd5c879e3c57","slug":"cla-mixed-isomer-preparations","display_name":"Study-specific mixed-isomer CLA preparations","entity_type_key":"chemical_species"},"object":{"id":"06575f23-de47-5bc0-b1a9-18ef226e4fbb","slug":"9-nitro-cla","display_name":"9-Nitro-conjugated linoleic acid","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"66cdc1bb-2d5c-537d-8bed-1c701785c670","stable_key":"ee4227e5-80d7-55e9-ada7-3c5a16f93ac9:cla-human-nitro-9-event","event_type":"observed_relationship","label":"Dietary lipid changed which nitrogen-oxide products formed.","description":"Adding CLA during labeled oral nitrite administration increased plasma 9-nitro-CLA formation.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"6f0cf7bd-c6e5-52d1-92f8-dd5c879e3c57","slug":"cla-mixed-isomer-preparations","display_name":"Study-specific mixed-isomer CLA preparations","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"06575f23-de47-5bc0-b1a9-18ef226e4fbb","slug":"9-nitro-cla","display_name":"9-Nitro-conjugated linoleic acid","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"03ffed32-aa18-5d63-96a4-8a7ebedaf7a9","slug":"nitrite","display_name":"Nitrite / NO2(-)","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Healthy-volunteer crossover; five returned for CLA coadministration.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Small acute study using investigational formulations; not a dosing recommendation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"CLA collection; isomer, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"conjugated-linoleic-acid","display_name":"Conjugated linoleic acid / CLA isomer family","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"Dietary lipid changed which nitrogen-oxide products formed.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Conjugated Linoleic Acid Modulates Clinical Responses to Oral Nitrite and Nitrate. · 2017 · https://pubmed.ncbi.nlm.nih.gov/28739973/ · DOI 10.1161/HYPERTENSIONAHA.117.09016","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"513ac3e7-7ac9-57ea-a923-87aff03ea622","evidence_kind":"source_excerpt","locator":"Lines 318-324","start_line":318,"end_line":324,"excerpt":"## cla-human-nitro-9\nDietary lipid changed which nitrogen-oxide products formed.\nAdding CLA during labeled oral nitrite administration increased plasma 9-nitro-CLA formation.\nModel: Healthy-volunteer crossover; five returned for CLA coadministration.\nLimitations: Small acute study using investigational formulations; not a dosing recommendation.\nEvidence access: Primary abstract\nConjugated Linoleic Acid Modulates Clinical Responses to Oral Nitrite and Nitrate. · 2017 · https://pubmed.ncbi.nlm.nih.gov/28739973/ · DOI 10.1161/HYPERTENSIONAHA.117.09016","model_system":"Healthy-volunteer crossover; five returned for CLA coadministration.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"45cfa6e3-2e7d-57c1-8c35-65302b7b71db","stable_key":"import-ee4227e5-80d7-55e9-ada7-3c5a16f93ac9","title":"Conjugated linoleic acid: isomers, signaling, nutrient interactions and discovery (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. 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