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(2021). https://pubmed.ncbi.nlm.nih.gov/33981038/ DOI: 10.1038/s41586-021-03539-7","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Mitochondrial ferroptosis defense","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"0378fc4e-a170-5a28-a53e-50940a7575ca","evidence_kind":"source_excerpt","locator":"Lines 814-825","start_line":814,"end_line":825,"excerpt":"### coq10-dhodh-quinol\nThe study reported DHODH-dependent ubiquinol generation as a mitochondrial ferroptosis-defense pathway.\nCondition category: normal\nnutrient_topic: Coenzyme Q10 research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A pyrimidine-synthesis enzyme can also contribute reduced CoQ in the studied system.\norganism: Human cancer-cell and tumor models\ntissue_or_cell_type: Mitochondrial ferroptosis defense\nexperimental_model: Genetic and pharmacological cancer-cell studies\nlimitations: Pharmacological attribution and relative DHODH contribution were directly challenged in 2023; preserve the dispute rather than generalizing to dietary CoQ effects.\nexposure: DHODH loss or brequinar, with GPX4 inhibition\nevidence_span: {\"source_cache\": \"artifacts/coq10-research/33981038.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"b1af5a97412b5ebf797083a069385c4ed98258e68845692732448bfe061a453b\", \"start_char\": 0, \"end_char\": 1716, \"text_sha256\": \"b1af5a97412b5ebf797083a069385c4ed98258e68845692732448bfe061a453b\"}\n[coq10-p33981038] DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer. 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