{"id":"7e533d41-c762-54d5-8890-acdd6ff11fed","stable_key":"1deb434a-3547-51a0-a038-87b1ce79ec38:vd-heaney-fat-d3","predicate":"increases","statement":"Subcutaneous adipose content of the administered D3 increased by 104 micrograms/kg.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"d6e611dc-a87e-5d44-8be9-a6aba20d438e","mechanism_event_label":"The administered form was also measured in fat tissue.","subject":{"id":"b162e431-b442-5400-9335-ec91f7875a4e","slug":"cholecalciferol","display_name":"Cholecalciferol","entity_type_key":"small_molecule"},"object":{"id":"02f75d21-d360-580a-a2a3-d3115422ddb6","slug":"subcutaneous-d3-content","display_name":"Subcutaneous adipose vitamin D3 content","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"d6e611dc-a87e-5d44-8be9-a6aba20d438e","stable_key":"1deb434a-3547-51a0-a038-87b1ce79ec38:vd-heaney-fat-d3-event","event_type":"observed_intervention","label":"The administered form was also measured in fat tissue.","description":"Subcutaneous adipose content of the administered D3 increased by 104 micrograms/kg.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"b162e431-b442-5400-9335-ec91f7875a4e","slug":"cholecalciferol","display_name":"Cholecalciferol","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"02f75d21-d360-580a-a2a3-d3115422ddb6","slug":"subcutaneous-d3-content","display_name":"Subcutaneous adipose vitamin D3 content","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"false","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Single-blind randomized D2/D3 comparison in 33 adults; weekly dosing for 12 weeks","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"D2 or D3 50, 000 IU orally each week for 12 weeks.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"This weekly regimen and marker response do not establish a universal conversion factor or superiority for every clinical endpoint. This is vitamer-specific content, not the disputed total-fat unit in the abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin D2 and D3 research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-d","display_name":"Vitamin D2 and D3","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The administered form was also measured in fat tissue.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[heaney2011] Vitamin D(3) is more potent than vitamin D(2) in humans. (2011). https://pubmed.ncbi.nlm.nih.gov/21177785/ DOI: 10.1210/jc.2010-2230","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Subcutaneous adipose tissue","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"363873da-7230-5691-974d-7d357aa6d500","evidence_kind":"source_excerpt","locator":"Lines 1340-1351","start_line":1340,"end_line":1351,"excerpt":"### vd-heaney-fat-d3\nSubcutaneous adipose content of the administered D3 increased by 104 micrograms/kg.\nCondition category: normal\nnutrient_topic: Vitamin D2 and D3 research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The administered form was also measured in fat tissue.\norganism: Homo sapiens\ntissue_or_cell_type: Subcutaneous adipose tissue\nexperimental_model: Single-blind randomized D2/D3 comparison in 33 adults; weekly dosing for 12 weeks\nlimitations: This weekly regimen and marker response do not establish a universal conversion factor or superiority for every clinical endpoint. This is vitamer-specific content, not the disputed total-fat unit in the abstract.\nexposure: D2 or D3 50, 000 IU orally each week for 12 weeks.\ncross_nutrient: false\n[heaney2011] Vitamin D(3) is more potent than vitamin D(2) in humans. (2011). https://pubmed.ncbi.nlm.nih.gov/21177785/ DOI: 10.1210/jc.2010-2230","model_system":"Single-blind randomized D2/D3 comparison in 33 adults; weekly dosing for 12 weeks","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [heaney2011] Vitamin D(3) is more potent than vitamin D(2) in humans. (2011). https://pubmed.ncbi.nlm.nih.gov/21177785/ DOI: 10.1210/jc.2010-2230","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"c95c763c-5b31-5b3f-a2f8-2dfe5ef0d3ca","stable_key":"import-1deb434a-3547-51a0-a038-87b1ce79ec38","title":"Vitamin D2 and D3: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"51004bf0d78db6146b8f198b0688a3cc7d4ea9822415a9c034f4c8790fb4e38b","revision_id":"d52ff207-a311-5f24-96f4-462838792db5","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}