{"id":"7e2c0656-cc10-5edb-bec0-28b290130a7e","stable_key":"dff9f743-3766-5f20-a71e-d6d2bd5bfb6f:va-ttr-tissue-pool-boundary","predicate":"is-dispensable-for-measured","statement":"Ttr-null mice maintained normal retinol/retinyl-ester levels in the tested liver and extrahepatic tissues despite low plasma retinol.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"f673166a-c206-586f-9efb-1c5316153f82","mechanism_event_label":"Low blood retinol did not mean low stores in these sampled tissues.","subject":{"id":"8124a8cb-9669-5050-ba1d-b022d7f3beb5","slug":"ttr","display_name":"Transthyretin / TTR","entity_type_key":"protein"},"object":{"id":"8e5ccb39-3448-5a5b-9330-f368ac039410","slug":"tissue-retinoid-stores","display_name":"Tissue retinoid stores","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"f673166a-c206-586f-9efb-1c5316153f82","stable_key":"dff9f743-3766-5f20-a71e-d6d2bd5bfb6f:va-ttr-tissue-pool-boundary-event","event_type":"observed_intervention","label":"Low blood retinol did not mean low stores in these sampled tissues.","description":"Ttr-null mice maintained normal retinol/retinyl-ester levels in the tested liver and extrahepatic tissues despite low plasma retinol.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"029e59fb-83de-519a-bbeb-85b48586658c","slug":"ttr-loss","display_name":"Transthyretin loss","entity_type_key":"protein_state"},"role":"experimental-machinery-state","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"8124a8cb-9669-5050-ba1d-b022d7f3beb5","slug":"ttr","display_name":"Transthyretin / TTR","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"8e5ccb39-3448-5a5b-9330-f368ac039410","slug":"tissue-retinoid-stores","display_name":"Tissue retinoid stores","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; 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