{"id":"7e1253e3-4595-5237-93a6-81ed8344ce7d","stable_key":"ca8e9e6a-6953-51ec-b712-2b06398a416d:ra-human-intact-exposure","predicate":"reported_relationship","statement":"At the same 500-mg-RA extract dose, intact RA Cmax was 124.03 nM fasting and 85.95 nM fed.","claim_class":"observational","status":"source_recorded","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"305a4cbb-09ac-5966-896a-8382887d888e","mechanism_event_label":"At the same 500-mg-RA extract dose, intact RA Cmax was 124.03 nM fasting and 85.95 nM fed.","subject":{"id":"2d483be1-dd8d-54e4-bac4-1a364bd1488a","slug":"lemon-balm-ra-enriched-extract","display_name":"RA-enriched Melissa officinalis extract","entity_type_key":"botanical"},"object":{"id":"49499efb-bb8f-5821-ad59-d85edab4951d","slug":"human-intact-serum-ra","display_name":"Human serum unconjugated RA","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"305a4cbb-09ac-5966-896a-8382887d888e","stable_key":"ca8e9e6a-6953-51ec-b712-2b06398a416d:ra-human-intact-exposure-event","event_type":"experimental_observation","label":"At the same 500-mg-RA extract dose, intact RA Cmax was 124.03 nM fasting and 85.95 nM fed.","description":"### ra-human-intact-exposure\n\nAt the same 500-mg-RA extract dose, intact RA Cmax was 124.03 nM fasting and 85.95 nM fed.\nIntact means unconjugated, not unbound. Fasting intact AUC0-48 was 228.77 nmol h/L; the abstract mislabels the total AUC of 832.13 as intact.\nModel and exposure: 2015 human PK, Table 3.\nLimitations: Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.\nReference: Pharmacokinetics, Safety and Tolerability of Melissa officinalis Extract which Contained Rosmarinic Acid in Healthy Individuals: A Randomized Controlled Trial. | 2015 | https://pubmed.ncbi.nlm.nih.gov/25978046/ | https://pmc.ncbi.nlm.nih.gov/articles/PMC4433273/ | https://doi.org/10.1371/journal.pone.0126422 | Access: Primary full text: relevant Results/Methods and figure descriptions reviewed; supplements only where explicitly stated.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"2d483be1-dd8d-54e4-bac4-1a364bd1488a","slug":"lemon-balm-ra-enriched-extract","display_name":"RA-enriched Melissa officinalis extract","entity_type_key":"botanical"},"role":"recorded factor","stoichiometry":null,"state_label":"as reported","sequence_order":0,"notes":""},{"entity":{"id":"49499efb-bb8f-5821-ad59-d85edab4951d","slug":"human-intact-serum-ra","display_name":"Human serum unconjugated RA","entity_type_key":"cellular_process"},"role":"measured outcome","stoichiometry":null,"state_label":"not_reported","sequence_order":1,"notes":""},{"entity":{"id":"6072a4ae-d563-5466-a1b2-6d280255d346","slug":"rosmarinic-acid","display_name":"Rosmarinic acid","entity_type_key":"small_molecule"},"role":"unconjugated measured analyte","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text: relevant Results/Methods and figure descriptions reviewed; supplements only where explicitly stated.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"2015 human PK, Table 3.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"interpretation_status","value_text":"Recorded from source with stated access limits; ungraded, not independent replication.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Rosmarinic acid collection; exact intervention and molecular form govern interpretation.","comparator":null,"unit":null,"notes":"","entity":{"slug":"rosmarinic-acid","display_name":"Rosmarinic acid","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"At the same 500-mg-RA extract dose, intact RA Cmax was 124.03 nM fasting and 85.95 nM fed.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Pharmacokinetics, Safety and Tolerability of Melissa officinalis Extract which Contained Rosmarinic Acid in Healthy Individuals: A Randomized Controlled Trial. | https://pubmed.ncbi.nlm.nih.gov/25978046/ | https://pmc.ncbi.nlm.nih.gov/articles/PMC4433273/ | https://doi.org/10.1371/journal.pone.0126422","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"source_locator","value_text":"Reviewed reference ra-human-intact-exposure; Intact means unconjugated, not unbound. Fasting intact AUC0-48 was 228.77 nmol h/L; the abstract mislabels the total AUC of 832.13 as intact.","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"237ca71e-d4d0-5301-86a7-019ed89a6f10","evidence_kind":"source_excerpt","locator":"Lines 43-49","start_line":43,"end_line":49,"excerpt":"### ra-human-intact-exposure\n\nAt the same 500-mg-RA extract dose, intact RA Cmax was 124.03 nM fasting and 85.95 nM fed.\nIntact means unconjugated, not unbound. Fasting intact AUC0-48 was 228.77 nmol h/L; the abstract mislabels the total AUC of 832.13 as intact.\nModel and exposure: 2015 human PK, Table 3.\nLimitations: Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.\nReference: Pharmacokinetics, Safety and Tolerability of Melissa officinalis Extract which Contained Rosmarinic Acid in Healthy Individuals: A Randomized Controlled Trial. | 2015 | https://pubmed.ncbi.nlm.nih.gov/25978046/ | https://pmc.ncbi.nlm.nih.gov/articles/PMC4433273/ | https://doi.org/10.1371/journal.pone.0126422 | Access: Primary full text: relevant Results/Methods and figure descriptions reviewed; supplements only where explicitly stated.","model_system":"2015 human PK, Table 3.","directness":"reported_statement","verification_status":"source_recorded","notes":"Original paraphrase in the retained reviewed reference, not a verbatim primary-paper quotation. Access level is explicit.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"606cff22-a6ed-59cd-a84d-87f44c59dc25","stable_key":"import-ca8e9e6a-6953-51ec-b712-2b06398a416d","title":"Rosmarinic acid: detailed mechanisms of action (reviewed 10 October 2026)","document_type":"imported_text","citation_label":"AI-assisted original curation of primary studies; claim-local access and experimental limitations stated. Includes original-draft correction history. No independent replication claimed.","file_path":"","sha256":"684b4eab1dc2c0057f679109770af0de9340af5cd933377b590298cf8a752956","revision_id":"4028d9c5-fb17-54c5-b72c-c6d21678a832","review_status":"source_recorded","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}