{"id":"7e11a96b-635c-5ec8-923c-6eaa927e29af","stable_key":"fd37d270-3395-56d6-9f1c-ddda56e606f6:arg-amd-reaction","predicate":"decarboxylated_to","statement":"AMD1 decarboxylation generates the aminopropyl donor used in polyamine synthesis.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"ff668727-ebc6-591d-b149-4b254a0adbd4","mechanism_event_label":"SAM must be chemically changed before this branch uses it.","subject":{"id":"825f2da2-01bc-5874-a3c6-64f5ac867db5","slug":"s-adenosylmethionine","display_name":"S-Adenosyl-L-methionine","entity_type_key":"small_molecule"},"object":{"id":"ae5a8bbb-59e5-503a-94c9-51b512d7c7b3","slug":"decarboxylated-sam","display_name":"Decarboxylated S-adenosylmethionine","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"ff668727-ebc6-591d-b149-4b254a0adbd4","stable_key":"fd37d270-3395-56d6-9f1c-ddda56e606f6:arg-amd-reaction-event","event_type":"observed_relationship","label":"SAM must be chemically changed before this branch uses it.","description":"AMD1 decarboxylation generates the aminopropyl donor used in polyamine synthesis.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"825f2da2-01bc-5874-a3c6-64f5ac867db5","slug":"s-adenosylmethionine","display_name":"S-Adenosyl-L-methionine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"ae5a8bbb-59e5-503a-94c9-51b512d7c7b3","slug":"decarboxylated-sam","display_name":"Decarboxylated S-adenosylmethionine","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"19cac4f8-8921-5216-8ee1-c70e6a1220d7","slug":"amd1","display_name":"Human S-adenosylmethionine decarboxylase / AMD1","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human S-adenosylmethionine decarboxylase biochemical study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Do not confuse aminopropyl donation with GAMT methyl transfer.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Arginine collection; tissue, species, dose and formulation distinctions retained.","comparator":null,"unit":null,"notes":"","entity":{"slug":"arginine","display_name":"L-Arginine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"SAM must be chemically changed before this branch uses it.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Structural basis for putrescine activation of human S-adenosylmethionine decarboxylase. · 2008 · https://pubmed.ncbi.nlm.nih.gov/19053272/ · DOI 10.1021/bi801732m","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"f4716bf0-950a-504d-8527-74f87dc197e9","evidence_kind":"source_excerpt","locator":"Lines 150-156","start_line":150,"end_line":156,"excerpt":"## arg-amd-reaction\nSAM must be chemically changed before this branch uses it.\nAMD1 decarboxylation generates the aminopropyl donor used in polyamine synthesis.\nModel: Human S-adenosylmethionine decarboxylase biochemical study.\nLimitations: Do not confuse aminopropyl donation with GAMT methyl transfer.\nEvidence access: Primary abstract\nStructural basis for putrescine activation of human S-adenosylmethionine decarboxylase. · 2008 · https://pubmed.ncbi.nlm.nih.gov/19053272/ · DOI 10.1021/bi801732m","model_system":"Human S-adenosylmethionine decarboxylase biochemical study.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; primary evidence access stated per claim.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"bb9a67ea-904f-5b8a-93a4-459081212bdd","stable_key":"import-fd37d270-3395-56d6-9f1c-ddda56e606f6","title":"L-Arginine: transport, metabolic branches, nutrient interactions, availability and discovery questions (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"ec0e9a3fb72b7485534e4372a074ac7624a399ff962e55690eb462217b5149ec","revision_id":"af027270-5535-51ae-85ff-9c76c518c962","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}