{"id":"7d869ecc-b512-500b-a3db-05303516c4be","stable_key":"5102beb6-9f61-500e-af10-9ac63649e0b7:k-tcell-kv13-efflux","predicate":"restores-under-local-potassium-excess","statement":"Kv1.3 overexpression lowered intracellular K and improved antitumor T-cell function; engineered cells improved melanoma control in mice.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"bb63b65e-a834-5f8e-8a29-8ecc17f0fbd4","mechanism_event_label":"Increasing potassium exit rescued cells in this tumor model.","subject":{"id":"3cae6e59-a64b-592a-81de-a8c0c1ee3918","slug":"kcna3","display_name":"Kv1.3 / KCNA3","entity_type_key":"protein"},"object":{"id":"8dbcdf33-282e-5dce-80a0-06e171ba139d","slug":"t-cell-effector-function","display_name":"T-cell effector function","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"bb63b65e-a834-5f8e-8a29-8ecc17f0fbd4","stable_key":"5102beb6-9f61-500e-af10-9ac63649e0b7:k-tcell-kv13-efflux-event","event_type":"biochemical_relationship","label":"Increasing potassium exit rescued cells in this tumor model.","description":"Kv1.3 overexpression lowered intracellular K and improved antitumor T-cell function; engineered cells improved melanoma control in mice.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"5dd31e52-f51e-51f3-880e-240abcc0ab1d","slug":"potassium-ion","display_name":"Potassium ion","entity_type_key":"ion"},"role":"exported ion","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"8c7b3fef-22fb-5b65-9b51-59f776234bc3","slug":"intracellular-potassium-concentration","display_name":"Intracellular potassium concentration","entity_type_key":"cellular_process"},"role":"measured intermediate","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"3cae6e59-a64b-592a-81de-a8c0c1ee3918","slug":"kcna3","display_name":"Kv1.3 / KCNA3","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"8dbcdf33-282e-5dce-80a0-06e171ba139d","slug":"t-cell-effector-function","display_name":"T-cell effector function","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"Engineered T cells, culture and adoptive transfer.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Genetic cell intervention cannot be translated into a dietary potassium claim.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Potassium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"potassium","display_name":"Potassium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Mouse with human-cell complementary assays","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Increasing potassium exit rescued cells in this tumor model.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[eil-2016-tcells] Ionic immune suppression within the tumour microenvironment limits T cell effector function (2016). https://pmc.ncbi.nlm.nih.gov/articles/PMC5204372/ DOI: 10.1038/nature19364","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Tumor-infiltrating T cells","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"47dbb312-b3db-5137-a66b-3f8a2aa40687","evidence_kind":"source_excerpt","locator":"Lines 913-922","start_line":913,"end_line":922,"excerpt":"### k-tcell-kv13-efflux\nKv1.3 overexpression lowered intracellular K and improved antitumor T-cell function; engineered cells improved melanoma control in mice.\nCondition category: normal\nnutrient_topic: Potassium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Increasing potassium exit rescued cells in this tumor model.\norganism: Mouse with human-cell complementary assays\ntissue_or_cell_type: Tumor-infiltrating T cells\nexperimental_model: Engineered T cells, culture and adoptive transfer.\nlimitations: Genetic cell intervention cannot be translated into a dietary potassium claim.\n[eil-2016-tcells] Ionic immune suppression within the tumour microenvironment limits T cell effector function (2016). https://pmc.ncbi.nlm.nih.gov/articles/PMC5204372/ DOI: 10.1038/nature19364","model_system":"Engineered T cells, culture and adoptive transfer.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. 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