{"id":"7d0b3d72-ca3d-5957-9498-62e5654136ca","stable_key":"33bef151-bdc7-5892-aff6-0345ab149739:three-years-of-nsk-sd-does-not-change-blood-pressure","predicate":"does_not_change","statement":"There was no significant effect on blood pressure over the same three years.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"87027f4d-32ec-5351-8482-c5eb30549f44","mechanism_event_label":"There was no significant effect on blood pressure over the same three years.","subject":{"id":"9910223c-2a27-5d75-8003-91d72e71be9a","slug":"nsk-sd","display_name":"NSK-SD fermented soybean extract","entity_type_key":"chemical_species"},"object":{"id":"9eda1162-1823-5c43-8e7d-4f2e4858c353","slug":"blood-pressure","display_name":"Arterial blood pressure","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"87027f4d-32ec-5351-8482-c5eb30549f44","stable_key":"33bef151-bdc7-5892-aff6-0345ab149739:three-years-of-nsk-sd-does-not-change-blood-pressure-event","event_type":"observed_intervention","label":"There was no significant effect on blood pressure over the same three years.","description":"Arterial blood pressure","status":"provisional","compartment":null,"participants":[{"entity":{"id":"9910223c-2a27-5d75-8003-91d72e71be9a","slug":"nsk-sd","display_name":"NSK-SD fermented soybean extract","entity_type_key":"chemical_species"},"role":"acting component","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"9eda1162-1823-5c43-8e7d-4f2e4858c353","slug":"blood-pressure","display_name":"Arterial blood pressure","entity_type_key":"cellular_process"},"role":"component the finding is about","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"duration","value_text":"Median 3 years","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human (265 randomized, low cardiovascular risk)","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Nattokinase, 2,000 FU per day","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"This is the direct contradiction of the eight-week blood-pressure trials and of the pooled estimate. The populations differ: these participants were low-risk and not selected for elevated blood pressure.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"organism","value_text":"Human (265 randomized, low cardiovascular risk)","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"There was no significant effect on blood pressure over the same three years.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Nattokinase atherothrombotic prevention study: A randomized controlled trial. (2021) https://pubmed.ncbi.nlm.nih.gov/33843667/ DOI: 10.3233/CH-211147","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"In vivo, oral","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Arterial blood pressure","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"58e9e574-a047-56b8-b9a0-15346ef3b27a","evidence_kind":"source_excerpt","locator":"Lines 1126-1126","start_line":1126,"end_line":1126,"excerpt":"There was no significant effect on blood pressure over the same three years.","model_system":"Human (265 randomized, low cardiovascular risk)","directness":"reported_statement","verification_status":"source_derived_draft","notes":"","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"41cb127c-1c23-53aa-b7d0-5ec7f6fa3c99","stable_key":"import-33bef151-bdc7-5892-aff6-0345ab149739","title":"Nattokinase: what the purified enzyme cleaves, what survives being eaten, and the gap between the two (2026-09-23)","document_type":"imported_text","citation_label":"Original AI-assisted curation built from a supplied entity-first document of 105 entities and 129 claims. Every reference in that document was resolved against live PubMed with its abstract read and its DOI cross-checked on 2026-09-23, and the EFSA novel-food opinion was retrieved and read in full. That check corrected two PMIDs that pointed at unrelated papers, two DOIs, and two papers recorded as carrying no erratum that do carry one; it also reversed three findings the supplied document had stated backwards. Two papers carry a published correction, recorded as such and not as a retraction. Three sources are not indexed in PubMed and are cited by what they have. Laboratory lineages are recorded, so the four papers from one group, the three from another and the two readings of a single applicant dossier cannot be counted as separate lines of support. Study-specific doses, units, populations and limitations retained; activity units are never converted between systems. Not publisher full text.","file_path":"","sha256":"34fc46e0e849d06bfa13cb099a79b50679dd6fd0de8a5a0575326afdde3259c1","revision_id":"efd063e6-e982-5f6e-a4b8-6f2ffe4185ce","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[{"id":"d607bfaa-0e02-5c87-ad79-6164c3434b00","title":"Short trials find a blood-pressure reduction and the one long trial finds none","kind":"context_difference","status":"open","why":"Two eight-week randomized trials and a meta-analysis of six report systolic reductions of roughly 3.5 to 5.5 mmHg. The three-year randomized trial at the same 2,000 FU dose found no effect on blood pressure at all. The populations differ: the short trials enrolled people with elevated blood pressure and the long trial enrolled low-risk adults not selected for it, so regression to the mean and a floor effect are both available explanations alongside a real difference in duration or population.","resolution":"Unresolved. A long trial in a hypertensive population has not been run.","created_at":"2026-09-23 07:55:19","record_type":"conflict","display_label":"Recorded conflict","record_url":"/conflicts/d607bfaa-0e02-5c87-ad79-6164c3434b00","sides":[{"conflict_id":"d607bfaa-0e02-5c87-ad79-6164c3434b00","ordinal":0,"label":"Eight weeks at 2,000 FU per day lowered blood pressure against placebo","revision_id":"efd063e6-e982-5f6e-a4b8-6f2ffe4185ce","start_line":994,"end_line":994,"quote":"Net changes of -5.55 mmHg systolic and -2.84 mmHg diastolic against placebo were reported after eight weeks at 2,000 FU per day.","source_key":"import-33bef151-bdc7-5892-aff6-0345ab149739","source_title":"Nattokinase: what the purified enzyme cleaves, what survives being eaten, and the gap between the two (2026-09-23)","claim_ids":["b540bd62-dbd2-557b-a0b4-fb1ab06f535e"]},{"conflict_id":"d607bfaa-0e02-5c87-ad79-6164c3434b00","ordinal":1,"label":"Three years at 2,000 FU per day did not change blood pressure","revision_id":"efd063e6-e982-5f6e-a4b8-6f2ffe4185ce","start_line":1126,"end_line":1126,"quote":"There was no significant effect on blood pressure over the same three years.","source_key":"import-33bef151-bdc7-5892-aff6-0345ab149739","source_title":"Nattokinase: what the purified enzyme cleaves, what survives being eaten, and the gap between the two (2026-09-23)","claim_ids":["7d0b3d72-ca3d-5957-9498-62e5654136ca"]}]}],"corrections":[],"research":null}