{"id":"7ce577bb-9584-5151-840a-8e198923cabd","stable_key":"09b23d0d-35e2-51ff-b1aa-b4f9227e4fa2:isoleucine-human-diet-association","predicate":"associates_with","statement":"Higher dietary isoleucine content was associated with higher BMI in the study human dietary analysis.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"45fe1735-5dfc-59e6-8cc7-a3d968266973","mechanism_event_label":"The human evidence here is an association, not a restriction trial.","subject":{"id":"c85b327e-f132-5d9a-8e4b-c2976fcc0373","slug":"isoleucine","display_name":"L-Isoleucine","entity_type_key":"small_molecule"},"object":{"id":"477e6ecf-b774-5aae-875a-d2474726078e","slug":"human-dietary-isoleucine-bmi","display_name":"Dietary isoleucine and BMI association","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"45fe1735-5dfc-59e6-8cc7-a3d968266973","stable_key":"09b23d0d-35e2-51ff-b1aa-b4f9227e4fa2:isoleucine-human-diet-association-event","event_type":"observed_relationship","label":"The human evidence here is an association, not a restriction trial.","description":"Higher dietary isoleucine content was associated with higher BMI in the study human dietary analysis.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"c85b327e-f132-5d9a-8e4b-c2976fcc0373","slug":"isoleucine","display_name":"L-Isoleucine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"477e6ecf-b774-5aae-875a-d2474726078e","slug":"human-dietary-isoleucine-bmi","display_name":"Dietary isoleucine and BMI association","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human food-frequency/dietary observational analysis.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Diet reporting, other dietary components and reverse causation can affect the result.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Isoleucine collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"isoleucine","display_name":"L-Isoleucine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The human evidence here is an association, not a restriction trial.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"The adverse metabolic effects of branched-chain amino acids are mediated by isoleucine and valine. · 2021 · https://pubmed.ncbi.nlm.nih.gov/33887198/ · DOI 10.1016/j.cmet.2021.03.025","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"e100154d-f38f-585a-ab71-0f82bd08384e","evidence_kind":"source_excerpt","locator":"Lines 410-416","start_line":410,"end_line":416,"excerpt":"## isoleucine-human-diet-association\nThe human evidence here is an association, not a restriction trial.\nHigher dietary isoleucine content was associated with higher BMI in the study human dietary analysis.\nModel: Human food-frequency/dietary observational analysis.\nLimitations: Diet reporting, other dietary components and reverse causation can affect the result.\nEvidence access: Primary full text\nThe adverse metabolic effects of branched-chain amino acids are mediated by isoleucine and valine. · 2021 · https://pubmed.ncbi.nlm.nih.gov/33887198/ · DOI 10.1016/j.cmet.2021.03.025","model_system":"Human food-frequency/dietary observational analysis.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"4b00f118-00fd-5cef-be97-13125eb958e9","stable_key":"import-09b23d0d-35e2-51ff-b1aa-b4f9227e4fa2","title":"L-Isoleucine: transport, translation, catabolism and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"2058ff0da379586994e7fda6ae0086c60fa3173542bfaf1fb3871ad3e09f9c6c","revision_id":"f32192d4-9913-5d35-acbc-cf90ff17995e","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}