{"id":"7cc87531-4671-5b32-b155-f218bd13b2dc","stable_key":"8182578e-8d21-598e-a3cb-e62d480d2251:myricetin-beta-cell-serca","predicate":"modulates","statement":"Myricetin counteracted high-glucose-associated loss of SERCA2b expression in rat beta-cell experiments.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"76912b61-3da1-5761-a142-ef3a758e1f0c","mechanism_event_label":"Beta-cell calcium handling and gene regulation are linked.","subject":{"id":"fafe05e7-4874-56e6-a42a-2ebf1ab2dd57","slug":"myricetin","display_name":"Myricetin","entity_type_key":"small_molecule"},"object":{"id":"ad839f42-2845-5af8-a9bf-a7102828d755","slug":"rat-atp2a2-serca2b","display_name":"Rat SERCA2b / Atp2a2 isoform","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"76912b61-3da1-5761-a142-ef3a758e1f0c","stable_key":"8182578e-8d21-598e-a3cb-e62d480d2251:myricetin-beta-cell-serca-event","event_type":"observed_relationship","label":"Beta-cell calcium handling and gene regulation are linked.","description":"Myricetin counteracted high-glucose-associated loss of SERCA2b expression in rat beta-cell experiments.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"fafe05e7-4874-56e6-a42a-2ebf1ab2dd57","slug":"myricetin","display_name":"Myricetin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"ad839f42-2845-5af8-a9bf-a7102828d755","slug":"rat-atp2a2-serca2b","display_name":"Rat SERCA2b / Atp2a2 isoform","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"e359bc15-e675-5d83-b0fe-1d70814e130b","slug":"calcium-ion","display_name":"Calcium ion","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Rat INS-1 cells and rat islets challenged with 30 mM glucose; myricetin 20 micromolar in the cell protocol.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Direct CDK5 binding was predicted by docking, not established by a binding experiment; expression is not a calcium-pump flux measurement.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Myricetin collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"myricetin","display_name":"Myricetin","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Beta-cell calcium handling and gene regulation are linked.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Myricetin Protects Against High Glucose-Induced β-Cell Apoptosis by Attenuating Endoplasmic Reticulum Stress via Inactivation of Cyclin-Dependent Kinase 5. · 2019 · https://pubmed.ncbi.nlm.nih.gov/30688049/ · DOI 10.4093/dmj.2018.0052","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"2eef9ff2-00d8-523a-8ff3-d34904336eb2","evidence_kind":"source_excerpt","locator":"Lines 524-530","start_line":524,"end_line":530,"excerpt":"## myricetin-beta-cell-serca\nBeta-cell calcium handling and gene regulation are linked.\nMyricetin counteracted high-glucose-associated loss of SERCA2b expression in rat beta-cell experiments.\nModel: Rat INS-1 cells and rat islets challenged with 30 mM glucose; myricetin 20 micromolar in the cell protocol.\nLimitations: Direct CDK5 binding was predicted by docking, not established by a binding experiment; expression is not a calcium-pump flux measurement.\nEvidence access: Primary abstract\nMyricetin Protects Against High Glucose-Induced β-Cell Apoptosis by Attenuating Endoplasmic Reticulum Stress via Inactivation of Cyclin-Dependent Kinase 5. · 2019 · https://pubmed.ncbi.nlm.nih.gov/30688049/ · DOI 10.4093/dmj.2018.0052","model_system":"Rat INS-1 cells and rat islets challenged with 30 mM glucose; myricetin 20 micromolar in the cell protocol.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"58045cd9-3b27-5469-bb4b-e1c6a9bdca34","stable_key":"import-8182578e-8d21-598e-a3cb-e62d480d2251","title":"Myricetin: metabolism, immune signaling, redox chemistry and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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