{"id":"7c85aac8-0cb2-5d27-a30c-34f3dad1a6a0","stable_key":"548ab9d6-3a9b-5bed-879c-17d03813b636:b2-rat-crypt-production","predicate":"restrains-deficiency-associated","statement":"Riboflavin-deficient weanling rats showed approximately doubled crypt-cell production and deeper small-intestinal crypts versus controls.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"7ac146aa-0de0-5d7d-8e50-ca4f952613df","mechanism_event_label":"The intestinal lining was renewed faster during deficiency.","subject":{"id":"86eb1eee-a8d1-539c-8c17-0911f69b6f1b","slug":"riboflavin","display_name":"Riboflavin (vitamin B2)","entity_type_key":"small_molecule"},"object":{"id":"6f1e45df-eb8b-5acc-b5e0-20e2b4eafe86","slug":"intestinal-crypt-cell-production","display_name":"Intestinal crypt cell production","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"7ac146aa-0de0-5d7d-8e50-ca4f952613df","stable_key":"548ab9d6-3a9b-5bed-879c-17d03813b636:b2-rat-crypt-production-event","event_type":"biochemical_relationship","label":"The intestinal lining was renewed faster during deficiency.","description":"Riboflavin-deficient weanling rats showed approximately doubled crypt-cell production and deeper small-intestinal crypts versus controls.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"86eb1eee-a8d1-539c-8c17-0911f69b6f1b","slug":"riboflavin","display_name":"Riboflavin (vitamin B2)","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"6f1e45df-eb8b-5acc-b5e0-20e2b4eafe86","slug":"intestinal-crypt-cell-production","display_name":"Intestinal crypt cell production","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"cross_nutrient","value_text":"Altered B2-dependent intestinal maintenance may affect endogenous iron retention.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_location","value_text":"Abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Riboflavin-deficient weanling rats; weight-matched and ad-libitum controls; intestinal histology and intraperitoneal 59Fe tracing.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Dietary riboflavin deficiency","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Association with iron loss does not prove that epithelial turnover alone caused it.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Riboflavin research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"riboflavin","display_name":"Riboflavin (vitamin B2)","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Rattus norvegicus","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The intestinal lining was renewed faster during deficiency.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[powers1993] A proposed intestinal mechanism for the effect of riboflavin deficiency on iron loss in the rat. (1993). https://pubmed.ncbi.nlm.nih.gov/8490008/ DOI: 10.1079/bjn19930055","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Upper and middle small intestine","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"0c491211-b17f-5e8d-89d6-f94900ca799e","evidence_kind":"source_excerpt","locator":"Lines 1444-1456","start_line":1444,"end_line":1456,"excerpt":"### b2-rat-crypt-production\nRiboflavin-deficient weanling rats showed approximately doubled crypt-cell production and deeper small-intestinal crypts versus controls.\nCondition category: nutrient_deficiency\nnutrient_topic: Riboflavin research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The intestinal lining was renewed faster during deficiency.\norganism: Rattus norvegicus\ntissue_or_cell_type: Upper and middle small intestine\nexperimental_model: Riboflavin-deficient weanling rats; weight-matched and ad-libitum controls; intestinal histology and intraperitoneal 59Fe tracing.\nlimitations: Association with iron loss does not prove that epithelial turnover alone caused it.\nexposure: Dietary riboflavin deficiency\ncross_nutrient: Altered B2-dependent intestinal maintenance may affect endogenous iron retention.\nevidence_location: Abstract\n[powers1993] A proposed intestinal mechanism for the effect of riboflavin deficiency on iron loss in the rat. 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