{"id":"7c34d6b2-18ee-596e-bc70-3b1122929adb","stable_key":"fd7915ff-856d-56c2-a118-4989693a7644:gingerols-8-netosis","predicate":"reduces","statement":"Adding 8-gingerol suppressed RNP-immune-complex-induced NET formation by human neutrophils.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"6c3e27ce-7eab-5888-b510-b3ae0424e8f9","mechanism_event_label":"Adding 8-gingerol suppressed RNP-immune-complex-induced NET formation by human neutrophils.","subject":{"id":"d15f1089-e355-5f5e-8c76-5021ade1dc75","slug":"8-gingerol","display_name":"8-Gingerol","entity_type_key":"small_molecule"},"object":{"id":"8e33e68d-d8e5-5a43-b88e-83c4316515c6","slug":"human-neutrophil-netosis","display_name":"NET formation by human neutrophils","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"6c3e27ce-7eab-5888-b510-b3ae0424e8f9","stable_key":"fd7915ff-856d-56c2-a118-4989693a7644:gingerols-8-netosis-event","event_type":"observed_relationship","label":"Adding 8-gingerol suppressed RNP-immune-complex-induced NET formation by human neutrophils.","description":"Adding 8-gingerol suppressed RNP-immune-complex-induced NET formation by human neutrophils.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"d15f1089-e355-5f5e-8c76-5021ade1dc75","slug":"8-gingerol","display_name":"8-Gingerol","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"8e33e68d-d8e5-5a43-b88e-83c4316515c6","slug":"human-neutrophil-netosis","display_name":"NET formation by human neutrophils","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"Individual gingerols 10 micromolar with RNP/anti-RNP immune complexes 10 micrograms/mL","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"3 h","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary open full text, results, figure legends and methods, plus PubMed metadata.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_scope","value_text":"literature_reviewed; model-specific source-derived curation, not universally established human effects","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Neutrophils isolated from healthy human donors","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Selected disease-relevant stimulus in isolated cells; not established treatment of lupus or antiphospholipid syndrome.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Gingerols collection; each molecular form and experimental preparation remains explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"gingerols","display_name":"Gingerols","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Neutrophils isolated from healthy human donors","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Adding 8-gingerol suppressed RNP-immune-complex-induced NET formation by human neutrophils.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Antineutrophil properties of natural gingerols in models of lupus. 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