{"id":"7bff364e-c565-52ec-8a93-c02cb157c20a","stable_key":"0f17db03-207f-5910-ac8e-13dfc2f378ce:mg-citrate-oxide-urinary-response","predicate":"produces_larger_urinary_response_than","statement":"The tested citrate oral load produced a larger urinary Mg increment than the oxide load in healthy volunteers.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"a25559be-6716-5c4e-b2c9-1eb5ccd8062a","mechanism_event_label":"A formulation difference was reflected in a short-term absorption proxy.","subject":{"id":"b248ac1c-e9c4-560e-b8a0-5e2757b03bcc","slug":"magnesium-citrate","display_name":"Magnesium citrate","entity_type_key":"chemical_species"},"object":{"id":"f3c2d75b-ad3c-554e-adbb-89ebea103e2b","slug":"magnesium-oxide","display_name":"Magnesium oxide","entity_type_key":"chemical_species"},"evidence_count":1,"mechanism_event":{"id":"a25559be-6716-5c4e-b2c9-1eb5ccd8062a","stable_key":"0f17db03-207f-5910-ac8e-13dfc2f378ce:mg-citrate-oxide-urinary-response-event","event_type":"observed_intervention","label":"A formulation difference was reflected in a short-term absorption proxy.","description":"The tested citrate oral load produced a larger urinary Mg increment than the oxide load in healthy volunteers.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"bff427ab-35f9-59c2-bb24-fd5953bbaec2","slug":"magnesium-ion","display_name":"Mg2+","entity_type_key":"ion"},"role":"measured_ion","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"a298b414-0e07-568d-a469-d8aa3e8b8c14","slug":"urinary-magnesium-excretion","display_name":"Urinary magnesium excretion","entity_type_key":"cellular_process"},"role":"measured_endpoint","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"b248ac1c-e9c4-560e-b8a0-5e2757b03bcc","slug":"magnesium-citrate","display_name":"Magnesium citrate","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"f3c2d75b-ad3c-554e-adbb-89ebea103e2b","slug":"magnesium-oxide","display_name":"Magnesium oxide","entity_type_key":"chemical_species"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"Magnesium chemical form -> absorption proxy.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Healthy-volunteer oral-load comparison.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"25 mmol Mg experimental oral loads; historical study exposure, not dosage advice.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Urinary response is not tissue restoration or proof of superior clinical outcomes.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Magnesium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"magnesium","display_name":"Magnesium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A formulation difference was reflected in a short-term absorption proxy.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[mg-lindberg1990] Magnesium bioavailability from magnesium citrate and magnesium oxide (1990). https://pubmed.ncbi.nlm.nih.gov/2407766/ DOI: 10.1080/07315724.1990.10720349","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Simulated gastric solutions or human urinary Mg response, as specified in model","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"465016a3-97ca-54c5-a2e6-9302974f6fd8","evidence_kind":"source_excerpt","locator":"Lines 1640-1651","start_line":1640,"end_line":1651,"excerpt":"### mg-citrate-oxide-urinary-response\nThe tested citrate oral load produced a larger urinary Mg increment than the oxide load in healthy volunteers.\nCondition category: normal\nnutrient_topic: Magnesium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A formulation difference was reflected in a short-term absorption proxy.\norganism: Homo sapiens\ntissue_or_cell_type: Simulated gastric solutions or human urinary Mg response, as specified in model\nexperimental_model: Healthy-volunteer oral-load comparison.\nlimitations: Urinary response is not tissue restoration or proof of superior clinical outcomes.\ncross_nutrient: Magnesium chemical form -> absorption proxy.\nexposure: 25 mmol Mg experimental oral loads; historical study exposure, not dosage advice.\n[mg-lindberg1990] Magnesium bioavailability from magnesium citrate and magnesium oxide (1990). https://pubmed.ncbi.nlm.nih.gov/2407766/ DOI: 10.1080/07315724.1990.10720349","model_system":"Healthy-volunteer oral-load comparison.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. 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