{"id":"7bf8cf72-e9cb-5732-812a-9fe1065f2c68","stable_key":"ae1ed35d-8ce7-5936-9067-a641374bbf79:carnosine-mg-secondary","predicate":"reduces","statement":"Carnosine also inhibited protein modification caused by products formed by incubating lysine with methylglyoxal.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"16be9f01-87cc-5bde-931c-11fe53f99aae","mechanism_event_label":"Protection was tested against secondary reaction products too.","subject":{"id":"9998eb9b-0d09-58c9-885b-a442477dec8d","slug":"carnosine","display_name":"L-Carnosine / beta-alanyl-L-histidine","entity_type_key":"small_molecule"},"object":{"id":"251b076a-f938-5930-8c2f-225e785bc398","slug":"cell-free-lysine-mg-protein-modification","display_name":"Cell-free protein modification by lysine-methylglyoxal AGE products","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"16be9f01-87cc-5bde-931c-11fe53f99aae","stable_key":"ae1ed35d-8ce7-5936-9067-a641374bbf79:carnosine-mg-secondary-event","event_type":"observed_relationship","label":"Protection was tested against secondary reaction products too.","description":"Carnosine also inhibited protein modification caused by products formed by incubating lysine with methylglyoxal.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"9998eb9b-0d09-58c9-885b-a442477dec8d","slug":"carnosine","display_name":"L-Carnosine / beta-alanyl-L-histidine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"251b076a-f938-5930-8c2f-225e785bc398","slug":"cell-free-lysine-mg-protein-modification","display_name":"Cell-free protein modification by lysine-methylglyoxal AGE products","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"55c17a25-868a-5496-a200-88d9ec014558","slug":"methylglyoxal","display_name":"Methylglyoxal","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"5fff6664-209e-5c35-b88e-ac15c1c5fbc0","slug":"l-lysine","display_name":"L-Lysine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Cell-free lysine-MG AGE preparation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The study does not demonstrate removal of established tissue AGE deposits.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Carnosine collection; isomer, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"carnosine","display_name":"L-Carnosine / beta-alanyl-L-histidine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Protection was tested against secondary reaction products too.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Carnosine protects proteins against methylglyoxal-mediated modifications. · 1998 · https://pubmed.ncbi.nlm.nih.gov/9675080/ · DOI 10.1006/bbrc.1998.8806","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"6195ddf3-484f-51d5-8357-352a831b343f","evidence_kind":"source_excerpt","locator":"Lines 260-266","start_line":260,"end_line":266,"excerpt":"## carnosine-mg-secondary\nProtection was tested against secondary reaction products too.\nCarnosine also inhibited protein modification caused by products formed by incubating lysine with methylglyoxal.\nModel: Cell-free lysine-MG AGE preparation.\nLimitations: The study does not demonstrate removal of established tissue AGE deposits.\nEvidence access: Primary abstract\nCarnosine protects proteins against methylglyoxal-mediated modifications. · 1998 · https://pubmed.ncbi.nlm.nih.gov/9675080/ · DOI 10.1006/bbrc.1998.8806","model_system":"Cell-free lysine-MG AGE preparation.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"87dc5af2-4eb6-5980-b7e0-bf3697b1156e","stable_key":"import-ae1ed35d-8ce7-5936-9067-a641374bbf79","title":"Carnosine: synthesis, transport, carbonyl chemistry and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. 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