{"id":"7be80581-165c-58a1-a64a-38b70cf3ba48","stable_key":"e0ea2d6a-7429-5e9f-b774-41e5e3288da3:e-clin-select-baseline-selenium","predicate":"risk_association_varies_by","statement":"In the SELECT secondary analysis, vitamin E alone increased total prostate-cancer risk by 63% among men below the 40th percentile of baseline toenail selenium; a significant effect was not found above that split.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"d0dc5838-6cb5-5b32-b457-a87ed4968011","mechanism_event_label":"Baseline selenium measurements helped identify different trial outcomes, but did not establish a safe supplement combination.","subject":{"id":"10597737-a327-5b5b-9b97-517734df10c4","slug":"all-rac-alpha-tocopheryl-acetate","display_name":"All-rac-alpha-tocopheryl acetate","entity_type_key":"small_molecule"},"object":{"id":"683e9449-f86a-53cb-b397-8a2ea82fcad7","slug":"prostate-cancer-incidence","display_name":"Prostate cancer incidence","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"d0dc5838-6cb5-5b32-b457-a87ed4968011","stable_key":"e0ea2d6a-7429-5e9f-b774-41e5e3288da3:e-clin-select-baseline-selenium-event","event_type":"observed_intervention","label":"Baseline selenium measurements helped identify different trial outcomes, but did not establish a safe supplement combination.","description":"In the SELECT secondary analysis, vitamin E alone increased total prostate-cancer risk by 63% among men below the 40th percentile of baseline toenail selenium; a significant effect was not found above that split.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"dc89d7e2-8f89-577b-838f-42bf5d8ec7c8","slug":"selenium","display_name":"Selenium","entity_type_key":"nutrient_element"},"role":"baseline_biomarker","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"10597737-a327-5b5b-9b97-517734df10c4","slug":"all-rac-alpha-tocopheryl-acetate","display_name":"All-rac-alpha-tocopheryl acetate","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"683e9449-f86a-53cb-b397-8a2ea82fcad7","slug":"prostate-cancer-incidence","display_name":"Prostate cancer incidence","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"cross_nutrient","value_text":"true","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Secondary case-cohort analysis nested within SELECT; 1739 total cases and 3117 sampled cohort members","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Trial supplementation analyzed by baseline toenail selenium; E-alone comparison used below versus at/above the 40th percentile.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Exploratory subgroup thresholds are cohort percentiles, not deficiency thresholds; baseline selenium was not randomized. Does not justify adding selenium to make high-dose vitamin E safe.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin E research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-e","display_name":"Vitamin E","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Baseline selenium measurements helped identify different trial outcomes, but did not establish a safe supplement combination.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[e-clin-select2014] Baseline selenium status and effects of selenium and vitamin e supplementation on prostate cancer risk. (2014). https://pubmed.ncbi.nlm.nih.gov/24563519/ DOI: 10.1093/jnci/djt456","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Prostate and toenail selenium biomarker","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"e6214eb3-2492-5758-b888-7fdc556021e0","evidence_kind":"source_excerpt","locator":"Lines 1310-1321","start_line":1310,"end_line":1321,"excerpt":"### e-clin-select-baseline-selenium\nIn the SELECT secondary analysis, vitamin E alone increased total prostate-cancer risk by 63% among men below the 40th percentile of baseline toenail selenium; a significant effect was not found above that split.\nCondition category: biomarker_context\nnutrient_topic: Vitamin E research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Baseline selenium measurements helped identify different trial outcomes, but did not establish a safe supplement combination.\norganism: Homo sapiens\ntissue_or_cell_type: Prostate and toenail selenium biomarker\nexperimental_model: Secondary case-cohort analysis nested within SELECT; 1739 total cases and 3117 sampled cohort members\nlimitations: Exploratory subgroup thresholds are cohort percentiles, not deficiency thresholds; baseline selenium was not randomized. Does not justify adding selenium to make high-dose vitamin E safe.\nexposure: Trial supplementation analyzed by baseline toenail selenium; E-alone comparison used below versus at/above the 40th percentile.\ncross_nutrient: true\n[e-clin-select2014] Baseline selenium status and effects of selenium and vitamin e supplementation on prostate cancer risk. (2014). https://pubmed.ncbi.nlm.nih.gov/24563519/ DOI: 10.1093/jnci/djt456","model_system":"Secondary case-cohort analysis nested within SELECT; 1739 total cases and 3117 sampled cohort members","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [e-clin-select2014] Baseline selenium status and effects of selenium and vitamin e supplementation on prostate cancer risk. (2014). https://pubmed.ncbi.nlm.nih.gov/24563519/ DOI: 10.1093/jnci/djt456","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"3ac41dba-4727-5116-a556-ac3bbb0dc41c","stable_key":"import-e0ea2d6a-7429-5e9f-b774-41e5e3288da3","title":"Vitamin E: transport, membrane protection and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"a90b6565e092c6a2da07f74cf758792c2cf63b40746260c8ff12bd64322c36f4","revision_id":"956793d1-23e4-5397-9291-25c1732a8e02","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}