{"id":"7bc2e5a4-79c5-5c23-bd8c-2247723047cf","stable_key":"cab605fe-8a82-5191-9966-d19a9628c24c:betalains-indicaxanthin-hocl","predicate":"scavenges","statement":"Indicaxanthin reacted directly with hypochlorous acid in the kinetic assay.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"f8c2949b-1497-509a-b760-2eed55c0d46d","mechanism_event_label":"Indicaxanthin reacted directly with hypochlorous acid in the kinetic assay.","subject":{"id":"f2a6e469-05f0-5596-9054-da926389f584","slug":"indicaxanthin","display_name":"Indicaxanthin","entity_type_key":"small_molecule"},"object":{"id":"9bb71c3b-47d9-52bd-93ec-f2b06b3355a3","slug":"hypochlorous-acid","display_name":"Hypochlorous acid / HOCl","entity_type_key":"chemical_species"},"evidence_count":1,"mechanism_event":{"id":"f8c2949b-1497-509a-b760-2eed55c0d46d","stable_key":"cab605fe-8a82-5191-9966-d19a9628c24c:betalains-indicaxanthin-hocl-event","event_type":"observed_relationship","label":"Indicaxanthin reacted directly with hypochlorous acid in the kinetic assay.","description":"Indicaxanthin reacted directly with hypochlorous acid in the kinetic assay.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"f2a6e469-05f0-5596-9054-da926389f584","slug":"indicaxanthin","display_name":"Indicaxanthin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"9bb71c3b-47d9-52bd-93ec-f2b06b3355a3","slug":"hypochlorous-acid","display_name":"Hypochlorous acid / HOCl","entity_type_key":"chemical_species"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"Micromolar substrates; concentration-dependent chlorination assays","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"Rapid kinetic measurements at 25 degrees C; pH 7.0 and pH 5.0","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract; detailed exposure for PMID 23931157 additionally checked in publisher results. No uninspected full text is claimed.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_scope","value_text":"literature_reviewed; source-derived curation, not universally established human effects","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Purified human myeloperoxidase; cell-free chemistry","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"MPO substrates can stimulate or inhibit chlorination depending on conditions; not a universal MPO inhibitor.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Betalains collection; each molecular form, species, exposure and preparation remains explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"betalains","display_name":"Betalains","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Purified human myeloperoxidase; cell-free chemistry","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Indicaxanthin reacted directly with hypochlorous acid in the kinetic assay.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Mechanism of interaction of betanin and indicaxanthin with human myeloperoxidase and hypochlorous acid. (2005). https://pubmed.ncbi.nlm.nih.gov/15913556/ DOI: 10.1016/j.bbrc.2005.05.031","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"In vitro reagent addition","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"MPO redox cycle and HOCl solution","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"661c145c-5727-54c7-9642-a4d35b52090c","evidence_kind":"source_excerpt","locator":"Lines 167-175","start_line":167,"end_line":175,"excerpt":"## betalains-indicaxanthin-hocl\nIndicaxanthin reacted directly with hypochlorous acid in the kinetic assay.\nModel/species: Purified human myeloperoxidase; cell-free chemistry\nTissue: MPO redox cycle and HOCl solution\nExposure: Micromolar substrates; concentration-dependent chlorination assays\nRoute: In vitro reagent addition\nDuration: Rapid kinetic measurements at 25 degrees C; pH 7.0 and pH 5.0\nLimits: MPO substrates can stimulate or inhibit chlorination depending on conditions; not a universal MPO inhibitor.\nPrimary reference: Mechanism of interaction of betanin and indicaxanthin with human myeloperoxidase and hypochlorous acid. (2005). https://pubmed.ncbi.nlm.nih.gov/15913556/ DOI: 10.1016/j.bbrc.2005.05.031","model_system":"Purified human myeloperoxidase; cell-free chemistry","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact archived curation span; an original paraphrase with an individually identified primary reference.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"be94d093-444c-5729-8831-bc33b0ef2fd7","stable_key":"import-cab605fe-8a82-5191-9966-d19a9628c24c","title":"Betalains: mechanisms, molecular forms and cross-actor connections (2026-09-20)","document_type":"imported_text","citation_label":"Original AI-assisted curation of twelve primary research papers; study-specific PubMed/DOI links and limitations retained. Not publisher full text.","file_path":"","sha256":"adb4fb8586481a69da5d2fe5cf62ad1dae2509af524352673fc7427123eeda87","revision_id":"a328b3f9-66d2-59e2-bd8f-de651c3c7649","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}