{"id":"7bb459c3-3ab2-5704-abb8-f24a73f7fd0d","stable_key":"e0ea2d6a-7429-5e9f-b774-41e5e3288da3:e-clin-abetalipo-residual-retinopathy","predicate":"combined_treatment_does_not_fully_prevent","statement":"Despite combined vitamin A and E treatment, 11 of 13 ABL/HBL patients had subnormal mixed cone-rod electroretinogram amplitudes at long-term follow-up.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"3ceecb4b-d344-56d6-9ebd-6ca483198c15","mechanism_event_label":"Combined treatment did not fully prevent retinal abnormalities in every patient.","subject":{"id":"e67a0437-6900-5f53-8b03-c0a7ad6d92b6","slug":"vitamin-e","display_name":"Vitamin E","entity_type_key":"chemical_species"},"object":{"id":"46b54167-aa74-56f5-8df9-caa1827f00e3","slug":"retinal-function-in-abetalipoproteinemia","display_name":"Retinal function in abetalipoproteinemia","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"3ceecb4b-d344-56d6-9ebd-6ca483198c15","stable_key":"e0ea2d6a-7429-5e9f-b774-41e5e3288da3:e-clin-abetalipo-residual-retinopathy-event","event_type":"observed_intervention","label":"Combined treatment did not fully prevent retinal abnormalities in every patient.","description":"Despite combined vitamin A and E treatment, 11 of 13 ABL/HBL patients had subnormal mixed cone-rod electroretinogram amplitudes at long-term follow-up.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"ce392c9e-6483-5914-b18b-d6a2520dbbf6","slug":"vitamin-a","display_name":"Vitamin A","entity_type_key":"chemical_species"},"role":"coadministered_nutrient","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"e67a0437-6900-5f53-8b03-c0a7ad6d92b6","slug":"vitamin-e","display_name":"Vitamin E","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"46b54167-aa74-56f5-8df9-caa1827f00e3","slug":"retinal-function-in-abetalipoproteinemia","display_name":"Retinal function in abetalipoproteinemia","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"cross_nutrient","value_text":"true","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Longitudinal treated cohort; 10 abetalipoproteinemia and 3 homozygous hypobetalipoproteinemia patients","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Combined oral vitamins A and E; mean 11.7 years follow-up, range 4–20; exact doses unavailable in abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"No randomized A-only, E-only or untreated comparator. Residual retinal disease is compatible with partial benefit; it is not proof that supplementation has no effect.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin E research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-e","display_name":"Vitamin E","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Combined treatment did not fully prevent retinal abnormalities in every patient.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[e-clin-retina2001] Long-term assessment of combined vitamin A and E treatment for the prevention of retinal degeneration in abetalipoproteinaemia and hypobetalipoproteinaemia patients. (2001). https://pubmed.ncbi.nlm.nih.gov/11767031/ DOI: 10.1038/eye.2001.167","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Retina","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"3217972c-9f21-598d-a375-f5ca0305b3fd","evidence_kind":"source_excerpt","locator":"Lines 1466-1477","start_line":1466,"end_line":1477,"excerpt":"### e-clin-abetalipo-residual-retinopathy\nDespite combined vitamin A and E treatment, 11 of 13 ABL/HBL patients had subnormal mixed cone-rod electroretinogram amplitudes at long-term follow-up.\nCondition category: machinery_impairment\nnutrient_topic: Vitamin E research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Combined treatment did not fully prevent retinal abnormalities in every patient.\norganism: Homo sapiens\ntissue_or_cell_type: Retina\nexperimental_model: Longitudinal treated cohort; 10 abetalipoproteinemia and 3 homozygous hypobetalipoproteinemia patients\nlimitations: No randomized A-only, E-only or untreated comparator. Residual retinal disease is compatible with partial benefit; it is not proof that supplementation has no effect.\nexposure: Combined oral vitamins A and E; mean 11.7 years follow-up, range 4–20; exact doses unavailable in abstract.\ncross_nutrient: true\n[e-clin-retina2001] Long-term assessment of combined vitamin A and E treatment for the prevention of retinal degeneration in abetalipoproteinaemia and hypobetalipoproteinaemia patients. (2001). https://pubmed.ncbi.nlm.nih.gov/11767031/ DOI: 10.1038/eye.2001.167","model_system":"Longitudinal treated cohort; 10 abetalipoproteinemia and 3 homozygous hypobetalipoproteinemia patients","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [e-clin-retina2001] Long-term assessment of combined vitamin A and E treatment for the prevention of retinal degeneration in abetalipoproteinaemia and hypobetalipoproteinaemia patients. (2001). https://pubmed.ncbi.nlm.nih.gov/11767031/ DOI: 10.1038/eye.2001.167","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"3ac41dba-4727-5116-a556-ac3bbb0dc41c","stable_key":"import-e0ea2d6a-7429-5e9f-b774-41e5e3288da3","title":"Vitamin E: transport, membrane protection and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"a90b6565e092c6a2da07f74cf758792c2cf63b40746260c8ff12bd64322c36f4","revision_id":"956793d1-23e4-5397-9291-25c1732a8e02","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}