{"id":"7b79d4d0-1001-5d7a-98da-96426e92a0b0","stable_key":"ae1ed35d-8ce7-5936-9067-a641374bbf79:carnosine-negative-loading-ph","predicate":"did_not_change","statement":"In a 28-day randomized trial, beta-alanine did not significantly change measured muscle carnosine or exercise muscle pH versus placebo.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"b3d2ee5c-67c3-55b1-8dd1-42e3d849af17","mechanism_event_label":"Loading and buffering benefits were not demonstrated in every trial.","subject":{"id":"288f19a6-62f0-51fe-8e6d-366388b6b16d","slug":"beta-alanine","display_name":"Beta-alanine","entity_type_key":"small_molecule"},"object":{"id":"665976dc-bb8e-5173-9a52-3c9d62e355cb","slug":"human-exercise-muscle-ph","display_name":"Human exercising muscle pH","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"b3d2ee5c-67c3-55b1-8dd1-42e3d849af17","stable_key":"ae1ed35d-8ce7-5936-9067-a641374bbf79:carnosine-negative-loading-ph-event","event_type":"observed_relationship","label":"Loading and buffering benefits were not demonstrated in every trial.","description":"In a 28-day randomized trial, beta-alanine did not significantly change measured muscle carnosine or exercise muscle pH versus placebo.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"288f19a6-62f0-51fe-8e6d-366388b6b16d","slug":"beta-alanine","display_name":"Beta-alanine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"665976dc-bb8e-5173-9a52-3c9d62e355cb","slug":"human-exercise-muscle-ph","display_name":"Human exercising muscle pH","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"9998eb9b-0d09-58c9-885b-a442477dec8d","slug":"carnosine","display_name":"L-Carnosine / beta-alanyl-L-histidine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"644cc445-599f-50c6-9356-b714a5b71e9c","slug":"human-muscle-carnosine-content","display_name":"Human skeletal-muscle carnosine content","entity_type_key":"cellular_process"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Twenty men; 6.4 g/day; proton and phosphorus MRS.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Without demonstrated loading, the result cannot isolate whether added tissue carnosine would buffer exercise pH.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Carnosine collection; isomer, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"carnosine","display_name":"L-Carnosine / beta-alanyl-L-histidine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Loading and buffering benefits were not demonstrated in every trial.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"The Effects of β-Alanine Supplementation on Muscle pH and the Power-Duration Relationship during High-Intensity Exercise. · 2018 · https://pubmed.ncbi.nlm.nih.gov/29515455/ · DOI 10.3389/fphys.2018.00111","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"af6bb624-6f68-5766-9c90-d00768aecc2b","evidence_kind":"source_excerpt","locator":"Lines 228-234","start_line":228,"end_line":234,"excerpt":"## carnosine-negative-loading-ph\nLoading and buffering benefits were not demonstrated in every trial.\nIn a 28-day randomized trial, beta-alanine did not significantly change measured muscle carnosine or exercise muscle pH versus placebo.\nModel: Twenty men; 6.4 g/day; proton and phosphorus MRS.\nLimitations: Without demonstrated loading, the result cannot isolate whether added tissue carnosine would buffer exercise pH.\nEvidence access: Primary abstract\nThe Effects of β-Alanine Supplementation on Muscle pH and the Power-Duration Relationship during High-Intensity Exercise. · 2018 · https://pubmed.ncbi.nlm.nih.gov/29515455/ · DOI 10.3389/fphys.2018.00111","model_system":"Twenty men; 6.4 g/day; proton and phosphorus MRS.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"87dc5af2-4eb6-5980-b7e0-bf3697b1156e","stable_key":"import-ae1ed35d-8ce7-5936-9067-a641374bbf79","title":"Carnosine: synthesis, transport, carbonyl chemistry and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. 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