{"id":"7b6eaeb1-6fc0-5be9-8289-538e70b4ff79","stable_key":"7edf94bb-95c8-5234-9161-9eb338bb9b36:boron-bodybuilding-testosterone-null","predicate":"did_not_change","statement":"Boron supplementation did not significantly improve total or free testosterone relative to placebo in the seven-week bodybuilding study.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"438d9dc4-32b6-5001-9464-f3c799617d86","mechanism_event_label":"This controlled study did not find a testosterone benefit.","subject":{"id":"5144a867-de17-599d-baec-68500e3d40bd","slug":"boron","display_name":"Boron","entity_type_key":"nutrient_element"},"object":{"id":"dffa79cf-8fea-51e0-8839-6ca30a81cd6a","slug":"circulating-total-testosterone","display_name":"Circulating total testosterone concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"438d9dc4-32b6-5001-9464-f3c799617d86","stable_key":"7edf94bb-95c8-5234-9161-9eb338bb9b36:boron-bodybuilding-testosterone-null-event","event_type":"observed_intervention","label":"This controlled study did not find a testosterone benefit.","description":"Boron supplementation did not significantly improve total or free testosterone relative to placebo in the seven-week bodybuilding study.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"e78f545c-d4f7-53a4-b575-56c8fdb8b470","slug":"circulating-free-testosterone","display_name":"Circulating free testosterone concentration","entity_type_key":"cellular_process"},"role":"measured_endpoint","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"5144a867-de17-599d-baec-68500e3d40bd","slug":"boron","display_name":"Boron","entity_type_key":"nutrient_element"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"dffa79cf-8fea-51e0-8839-6ca30a81cd6a","slug":"circulating-total-testosterone","display_name":"Circulating total testosterone concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/boron-research/8508192.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"91f7c44f1eb8036fa77ee50cc2cc993c8fcf0bd65f26752b1c9d6d504db34770\", \"start_char\": 0, \"end_char\": 1032, \"text_sha256\": \"91f7c44f1eb8036fa77ee50cc2cc993c8fcf0bd65f26752b1c9d6d504db34770\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Placebo-controlled supplementation trial; 19 male bodybuilders aged 20–27","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Ten participants received 2.5 mg boron/day and nine placebo for seven weeks","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Small trial in a training context; null results do not prove absence of effects at all doses or in all populations. Training-related improvement in both groups was not a boron effect.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Boron research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"boron","display_name":"Boron","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"This controlled study did not find a testosterone benefit.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[boron-p8508192] The effect of boron supplementation on lean body mass, plasma testosterone levels, and strength in male bodybuilders. (1993). https://pubmed.ncbi.nlm.nih.gov/8508192/ DOI: 10.1123/ijsn.3.2.140","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Hormone, lean-mass and strength outcomes","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"45e0551a-2d39-5f73-80b8-be2cba6fb7bb","evidence_kind":"source_excerpt","locator":"Lines 976-987","start_line":976,"end_line":987,"excerpt":"### boron-bodybuilding-testosterone-null\nBoron supplementation did not significantly improve total or free testosterone relative to placebo in the seven-week bodybuilding study.\nCondition category: normal\nnutrient_topic: Boron research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: This controlled study did not find a testosterone benefit.\norganism: Human\ntissue_or_cell_type: Hormone, lean-mass and strength outcomes\nexperimental_model: Placebo-controlled supplementation trial; 19 male bodybuilders aged 20–27\nlimitations: Small trial in a training context; null results do not prove absence of effects at all doses or in all populations. Training-related improvement in both groups was not a boron effect.\nexposure: Ten participants received 2.5 mg boron/day and nine placebo for seven weeks\nevidence_span: {\"source_cache\": \"artifacts/boron-research/8508192.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"91f7c44f1eb8036fa77ee50cc2cc993c8fcf0bd65f26752b1c9d6d504db34770\", \"start_char\": 0, \"end_char\": 1032, \"text_sha256\": \"91f7c44f1eb8036fa77ee50cc2cc993c8fcf0bd65f26752b1c9d6d504db34770\"}\n[boron-p8508192] The effect of boron supplementation on lean body mass, plasma testosterone levels, and strength in male bodybuilders. (1993). https://pubmed.ncbi.nlm.nih.gov/8508192/ DOI: 10.1123/ijsn.3.2.140","model_system":"Placebo-controlled supplementation trial; 19 male bodybuilders aged 20–27","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [boron-p8508192] The effect of boron supplementation on lean body mass, plasma testosterone levels, and strength in male bodybuilders. (1993). https://pubmed.ncbi.nlm.nih.gov/8508192/ DOI: 10.1123/ijsn.3.2.140","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2d96c547-aeec-5d8b-9d31-1288da209f89","stable_key":"import-7edf94bb-95c8-5234-9161-9eb338bb9b36","title":"Boron: chemistry, nutrient interactions, low-intake studies and mechanistic uncertainties (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. 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