{"id":"7b6de6c6-8382-5543-a46b-c480516fed8e","stable_key":"dff9f743-3766-5f20-a71e-d6d2bd5bfb6f:va-retinyl-palmitate-calcitriol-calcium","predicate":"attenuates_acute_response_to","statement":"Retinyl palmitate attenuated the serum-calcium rise after calcitriol in the small crossover.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"58da371c-6215-50da-990e-de0870cd15ee","mechanism_event_label":"Vitamin A form and exposure changed a measured vitamin D/calcium response.","subject":{"id":"62e3f5bd-503b-5ea8-b102-966aa3b7319c","slug":"retinyl-palmitate","display_name":"All-trans-retinyl palmitate","entity_type_key":"small_molecule"},"object":{"id":"068b1eb6-c8bf-59d3-98a0-df623ad01b52","slug":"serum-calcium-concentration","display_name":"Serum calcium concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"58da371c-6215-50da-990e-de0870cd15ee","stable_key":"dff9f743-3766-5f20-a71e-d6d2bd5bfb6f:va-retinyl-palmitate-calcitriol-calcium-event","event_type":"observed_intervention","label":"Vitamin A form and exposure changed a measured vitamin D/calcium response.","description":"Retinyl palmitate attenuated the serum-calcium rise after calcitriol in the small crossover.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"f5156c24-108f-5746-b114-ed764e79a3f4","slug":"calcitriol","display_name":"Calcitriol","entity_type_key":"small_molecule"},"role":"coadministered_active_vitamin_d","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"e359bc15-e675-5d83-b0fe-1d70814e130b","slug":"calcium-ion","display_name":"Calcium ion","entity_type_key":"ion"},"role":"measured_mineral","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"62e3f5bd-503b-5ea8-b102-966aa3b7319c","slug":"retinyl-palmitate","display_name":"All-trans-retinyl palmitate","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"068b1eb6-c8bf-59d3-98a0-df623ad01b52","slug":"serum-calcium-concentration","display_name":"Serum calcium concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"Retinyl ester/calcitriol/calcium interaction.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Nine adults; acute blinded crossover.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"15 mg retinyl palmitate and/or 2 micrograms calcitriol; historical experiment, not advice.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Serum response is not a direct isotope absorption measurement, long-term fracture outcome or universal vitamin A:D ratio.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin A research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-a","display_name":"Vitamin A","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Vitamin A form and exposure changed a measured vitamin D/calcium response.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[va-johansson2001] Vitamin A antagonizes calcium response to vitamin D in man (2001). https://pubmed.ncbi.nlm.nih.gov/11585356/ DOI: 10.1359/jbmr.2001.16.10.1899","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Serum","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"9d7b1ab3-4df8-5267-9aa6-63784db33494","evidence_kind":"source_excerpt","locator":"Lines 1601-1612","start_line":1601,"end_line":1612,"excerpt":"### va-retinyl-palmitate-calcitriol-calcium\nRetinyl palmitate attenuated the serum-calcium rise after calcitriol in the small crossover.\nCondition category: normal\nnutrient_topic: Vitamin A research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Vitamin A form and exposure changed a measured vitamin D/calcium response.\norganism: Homo sapiens\ntissue_or_cell_type: Serum\nexperimental_model: Nine adults; acute blinded crossover.\nlimitations: Serum response is not a direct isotope absorption measurement, long-term fracture outcome or universal vitamin A:D ratio.\ncross_nutrient: Retinyl ester/calcitriol/calcium interaction.\nexposure: 15 mg retinyl palmitate and/or 2 micrograms calcitriol; historical experiment, not advice.\n[va-johansson2001] Vitamin A antagonizes calcium response to vitamin D in man (2001). https://pubmed.ncbi.nlm.nih.gov/11585356/ DOI: 10.1359/jbmr.2001.16.10.1899","model_system":"Nine adults; acute blinded crossover.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [va-johansson2001] Vitamin A antagonizes calcium response to vitamin D in man (2001). https://pubmed.ncbi.nlm.nih.gov/11585356/ DOI: 10.1359/jbmr.2001.16.10.1899","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"0c5474e2-be48-547b-b287-9c07a59c9ff1","stable_key":"import-dff9f743-3766-5f20-a71e-d6d2bd5bfb6f","title":"Vitamin A: forms, mechanisms, deficiency and excess (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"b217224b262abbd77d6a0c8c9beefff9c022fae4d31e2a5273915d769b9a6546","revision_id":"61008909-871f-575c-b5e2-21542689ea3c","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}