{"id":"7b67d53b-1039-58df-8a45-b7789dc4a946","stable_key":"1deb434a-3547-51a0-a038-87b1ce79ec38:vd-tripkovic-juice","predicate":"raises-total25-more-than-d2-in-juice","statement":"The D3-juice group had a 16.9 nmol/L greater incremental total 25(OH)D change than D2-juice (95% CI9.0–24.8; P<0.0001).","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"8f83248e-5e64-576a-b1dd-846112150c57","mechanism_event_label":"The matched-juice comparison also favored D3 for this blood marker.","subject":{"id":"b162e431-b442-5400-9335-ec91f7875a4e","slug":"cholecalciferol","display_name":"Cholecalciferol","entity_type_key":"small_molecule"},"object":{"id":"23768316-d34f-5f8e-9aee-af94fd13be8d","slug":"serum-total-25-hydroxyvitamin-d","display_name":"Serum total 25-hydroxyvitamin D concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"8f83248e-5e64-576a-b1dd-846112150c57","stable_key":"1deb434a-3547-51a0-a038-87b1ce79ec38:vd-tripkovic-juice-event","event_type":"observed_intervention","label":"The matched-juice comparison also favored D3 for this blood marker.","description":"The D3-juice group had a 16.9 nmol/L greater incremental total 25(OH)D change than D2-juice (95% CI9.0–24.8; P<0.0001).","status":"provisional","compartment":null,"participants":[{"entity":{"id":"6e1cf31c-f78e-596b-b1b3-70585cf9c948","slug":"ergocalciferol","display_name":"Ergocalciferol / vitamin D2","entity_type_key":"small_molecule"},"role":"comparator","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"b162e431-b442-5400-9335-ec91f7875a4e","slug":"cholecalciferol","display_name":"Cholecalciferol","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"23768316-d34f-5f8e-9aee-af94fd13be8d","slug":"serum-total-25-hydroxyvitamin-d","display_name":"Serum total 25-hydroxyvitamin D concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"false","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Randomized double-blind five-group food-fortification trial; 335 South Asian and white European women","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Daily 15 micrograms D2 or D3 in juice or biscuits versus placebo; 12 winter weeks.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Women aged 20–64 in the UK; food vehicles and dose differ from other trials. Marker superiority is not proof of better disease outcomes.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin D2 and D3 research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-d","display_name":"Vitamin D2 and D3","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The matched-juice comparison also favored D3 for this blood marker.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[tripkovic2017] Daily supplementation with 15 μg vitamin D2 compared with vitamin D3 to increase wintertime 25-hydroxyvitamin D status in healthy South Asian and white European women: a 12-wk randomized, placebo-controlled food-fortification trial. (2017). https://pubmed.ncbi.nlm.nih.gov/28679555/ DOI: 10.3945/ajcn.116.138693","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Human circulating measurements","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"78828566-e632-54a1-8e3e-5f4327d5d7af","evidence_kind":"source_excerpt","locator":"Lines 1366-1377","start_line":1366,"end_line":1377,"excerpt":"### vd-tripkovic-juice\nThe D3-juice group had a 16.9 nmol/L greater incremental total 25(OH)D change than D2-juice (95% CI9.0–24.8; P<0.0001).\nCondition category: normal\nnutrient_topic: Vitamin D2 and D3 research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The matched-juice comparison also favored D3 for this blood marker.\norganism: Homo sapiens\ntissue_or_cell_type: Human circulating measurements\nexperimental_model: Randomized double-blind five-group food-fortification trial; 335 South Asian and white European women\nlimitations: Women aged 20–64 in the UK; food vehicles and dose differ from other trials. Marker superiority is not proof of better disease outcomes.\nexposure: Daily 15 micrograms D2 or D3 in juice or biscuits versus placebo; 12 winter weeks.\ncross_nutrient: false\n[tripkovic2017] Daily supplementation with 15 μg vitamin D2 compared with vitamin D3 to increase wintertime 25-hydroxyvitamin D status in healthy South Asian and white European women: a 12-wk randomized, placebo-controlled food-fortification trial. (2017). https://pubmed.ncbi.nlm.nih.gov/28679555/ DOI: 10.3945/ajcn.116.138693","model_system":"Randomized double-blind five-group food-fortification trial; 335 South Asian and white European women","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [tripkovic2017] Daily supplementation with 15 μg vitamin D2 compared with vitamin D3 to increase wintertime 25-hydroxyvitamin D status in healthy South Asian and white European women: a 12-wk randomized, placebo-controlled food-fortification trial. (2017). https://pubmed.ncbi.nlm.nih.gov/28679555/ DOI: 10.3945/ajcn.116.138693","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"c95c763c-5b31-5b3f-a2f8-2dfe5ef0d3ca","stable_key":"import-1deb434a-3547-51a0-a038-87b1ce79ec38","title":"Vitamin D2 and D3: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"51004bf0d78db6146b8f198b0688a3cc7d4ea9822415a9c034f4c8790fb4e38b","revision_id":"d52ff207-a311-5f24-96f4-462838792db5","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}