{"id":"7b636120-c25f-514f-bd99-f39670e7c460","stable_key":"1310afbd-6010-586e-805d-551d846da421:b6-tnf-treatment-marker-change","predicate":"improvement_associated_with_plp_change","statement":"During TNF-inhibitor therapy, disease-activity changes correlated with PLP and HK: XA changes; good responders showed a 31% PLP increase.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"1ff7f06c-d2bd-5a6e-b742-c1e868dc79af","mechanism_event_label":"B6 markers changed while inflammation was being treated, without a B6 intervention.","subject":{"id":"631f2e58-aba7-5af2-8e4f-b31b3080a097","slug":"rheumatoid-arthritis-disease-activity","display_name":"Rheumatoid arthritis disease activity","entity_type_key":"cellular_process"},"object":{"id":"9907fbab-5dff-5e65-8891-1619ce01a4e2","slug":"plasma-plp-concentration","display_name":"Plasma pyridoxal 5-prime-phosphate concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"1ff7f06c-d2bd-5a6e-b742-c1e868dc79af","stable_key":"1310afbd-6010-586e-805d-551d846da421:b6-tnf-treatment-marker-change-event","event_type":"observed_intervention","label":"B6 markers changed while inflammation was being treated, without a B6 intervention.","description":"During TNF-inhibitor therapy, disease-activity changes correlated with PLP and HK: XA changes; good responders showed a 31% PLP increase.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"97fad2b5-a666-5acf-968f-4412f4869b51","slug":"hk-xa-ratio","display_name":"Plasma 3-hydroxykynurenine to xanthurenic acid ratio","entity_type_key":"cellular_process"},"role":"functional_marker","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"631f2e58-aba7-5af2-8e4f-b31b3080a097","slug":"rheumatoid-arthritis-disease-activity","display_name":"Rheumatoid arthritis disease activity","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"9907fbab-5dff-5e65-8891-1619ce01a4e2","slug":"plasma-plp-concentration","display_name":"Plasma pyridoxal 5-prime-phosphate concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"experimental_model","value_text":"Longitudinal 106 RA patients beginning TNF-inhibitor therapy, assessed at baseline and three months.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Clinical TNF inhibitors; not randomized B6 supplementation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Observational treatment-response association; cannot show B6 caused improvement. The 11% HK: XA decrease in good responders was not statistically significant (P=0.1).","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin B6 research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-b6","display_name":"Vitamin B6","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"B6 markers changed while inflammation was being treated, without a B6 intervention.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[b6-sande2019] Vitamin B-6 Status Correlates with Disease Activity in Rheumatoid Arthritis Patients During Treatment with TNFα Inhibitors (2019). https://pubmed.ncbi.nlm.nih.gov/31050750/ DOI: 10.1093/jn/nxz001","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Human blood and whole-body measurements","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"fa2367a8-c696-5d48-8f12-968614c7c21d","evidence_kind":"source_excerpt","locator":"Lines 1547-1557","start_line":1547,"end_line":1557,"excerpt":"### b6-tnf-treatment-marker-change\nDuring TNF-inhibitor therapy, disease-activity changes correlated with PLP and HK: XA changes; good responders showed a 31% PLP increase.\nCondition category: biomarker_context\nnutrient_topic: Vitamin B6 research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: B6 markers changed while inflammation was being treated, without a B6 intervention.\norganism: Homo sapiens\ntissue_or_cell_type: Human blood and whole-body measurements\nexperimental_model: Longitudinal 106 RA patients beginning TNF-inhibitor therapy, assessed at baseline and three months.\nlimitations: Observational treatment-response association; cannot show B6 caused improvement. The 11% HK: XA decrease in good responders was not statistically significant (P=0.1).\nexposure: Clinical TNF inhibitors; not randomized B6 supplementation.\n[b6-sande2019] Vitamin B-6 Status Correlates with Disease Activity in Rheumatoid Arthritis Patients During Treatment with TNFα Inhibitors (2019). https://pubmed.ncbi.nlm.nih.gov/31050750/ DOI: 10.1093/jn/nxz001","model_system":"Longitudinal 106 RA patients beginning TNF-inhibitor therapy, assessed at baseline and three months.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [b6-sande2019] Vitamin B-6 Status Correlates with Disease Activity in Rheumatoid Arthritis Patients During Treatment with TNFα Inhibitors (2019). https://pubmed.ncbi.nlm.nih.gov/31050750/ DOI: 10.1093/jn/nxz001","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"251773bb-16f5-5903-b135-db4a61d9dec4","stable_key":"import-1310afbd-6010-586e-805d-551d846da421","title":"Vitamin B6: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"ef0019b344b2219220f801a84d0d138ff6880c1be1a59540d9034bfa4334f61e","revision_id":"cac3555f-48af-5c52-a84e-add4482c87fb","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}