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(2015). https://pubmed.ncbi.nlm.nih.gov/26329789/ DOI: 10.1124/dmd.115.064790","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Olanzapine oxidation and conjugation","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"21ddc0b3-b86b-58da-bc21-d04f10e1ad6b","evidence_kind":"source_excerpt","locator":"Lines 701-712","start_line":701,"end_line":712,"excerpt":"### dim-olanzapine-1a2\nCYP1A2 played a major role in olanzapine 7-hydroxylation and also contributed to N-demethylation.\nCondition category: normal\nnutrient_topic: Diindolylmethane (DIM) research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: This independently identified route also contributes to olanzapine handling.\norganism: Human CYP, FMO and UGT enzymes\ntissue_or_cell_type: Olanzapine oxidation and conjugation\nexperimental_model: Human liver microsomes and recombinant enzyme phenotyping\nlimitations: In-vitro relative contributions; no DIM coadministration. Multiple routes limit prediction from CYP1A2 alone.\nexposure: Metabolite-specific assays including albumin effects\nevidence_span: {\"source_cache\": \"artifacts/dim-research/26329789.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"1f2f35be434034ef4788653d084a6b184b1b5a109d445591c4fd0fc94b36e543\", \"start_char\": 0, \"end_char\": 1657, \"text_sha256\": \"1f2f35be434034ef4788653d084a6b184b1b5a109d445591c4fd0fc94b36e543\"}\n[dim-p26329789] In Vitro Characterization of the Human Liver Microsomal Kinetics and Reaction Phenotyping of Olanzapine Metabolism. (2015). https://pubmed.ncbi.nlm.nih.gov/26329789/ DOI: 10.1124/dmd.115.064790","model_system":"Human liver microsomes and recombinant enzyme phenotyping","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. 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