{"id":"7ae3fe91-8e33-52a3-84f1-0f0ac7318c65","stable_key":"434e1e27-eb90-583a-956b-62472726ffba:ca-calcineurin-nfat1-regulation","predicate":"activates","statement":"Calcineurin binds NFAT1 and supports its reversible dephosphorylated, nuclear-active state during calcium stimulation.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"ee0d2687-3d87-5c42-a69a-7a55fd96a174","mechanism_event_label":"Calcineurin connects calcium signaling to NFAT1 activation.","subject":{"id":"27eef74a-1d9b-57b3-a245-82d452d6cb54","slug":"calcineurin","display_name":"Calcineurin","entity_type_key":"protein_complex"},"object":{"id":"3b51486f-fea8-56b9-9859-fbee74265c8f","slug":"nfatc2","display_name":"NFAT1 / NFATC2","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"ee0d2687-3d87-5c42-a69a-7a55fd96a174","stable_key":"434e1e27-eb90-583a-956b-62472726ffba:ca-calcineurin-nfat1-regulation-event","event_type":"regulation","label":"Calcineurin connects calcium signaling to NFAT1 activation.","description":"Calcineurin binds NFAT1 and supports its reversible dephosphorylated, nuclear-active state during calcium stimulation.","status":"provisional","compartment":{"slug":"cytosol","display_name":"Cytosol"},"participants":[{"entity":{"id":"27eef74a-1d9b-57b3-a245-82d452d6cb54","slug":"calcineurin","display_name":"Calcineurin","entity_type_key":"protein_complex"},"role":"phosphatase","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"3b51486f-fea8-56b9-9859-fbee74265c8f","slug":"nfatc2","display_name":"NFAT1 / NFATC2","entity_type_key":"protein"},"role":"regulated_substrate","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"e359bc15-e675-5d83-b0fe-1d70814e130b","slug":"calcium-ion","display_name":"Calcium ion","entity_type_key":"ion"},"role":"upstream_signal","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"bc9ed3a1-38d5-5bc3-b2a5-9f9f7633660b","slug":"cytosol","display_name":"Cytosol","entity_type_key":"organelle"},"role":"experimental_location","stoichiometry":null,"state_label":"","sequence_order":3,"notes":"Study location; presence here is not a separate transport or causal claim."},{"entity":{"id":"92a7a88e-c4dc-5d6d-babc-696ef95fff4b","slug":"nucleus","display_name":"Nucleus","entity_type_key":"organelle"},"role":"experimental_location","stoichiometry":null,"state_label":"","sequence_order":4,"notes":"Study location; presence here is not a separate transport or causal claim."}]},"contexts":[{"dimension":"compartment_description","value_text":"Cytosol and nucleus","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Murine T-cell experiments, inhibitor/chelation interventions and protein-binding assays","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"NFAT1-specific evidence; do not assign this calcium response to all NFAT proteins or NFAT5.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Calcium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"calcium","display_name":"Calcium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Mus musculus","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Calcineurin connects calcium signaling to NFAT1 activation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[ca-loh1996] Calcineurin binds the transcription factor NFAT1 and reversibly regulates its activity (1996). https://pubmed.ncbi.nlm.nih.gov/8631904/ DOI: 10.1074/jbc.271.18.10884","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"research_relationship_category","value_text":"regulation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"T lymphocytes","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"028352da-3b03-5f3d-a9fc-04683ef56ce0","evidence_kind":"source_excerpt","locator":"Lines 425-436","start_line":425,"end_line":436,"excerpt":"### ca-calcineurin-nfat1-regulation\nCalcineurin binds NFAT1 and supports its reversible dephosphorylated, nuclear-active state during calcium stimulation.\nCondition category: normal\nnutrient_topic: Calcium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Calcineurin connects calcium signaling to NFAT1 activation.\norganism: Mus musculus\ntissue_or_cell_type: T lymphocytes\nexperimental_model: Murine T-cell experiments, inhibitor/chelation interventions and protein-binding assays\nlimitations: NFAT1-specific evidence; do not assign this calcium response to all NFAT proteins or NFAT5.\nresearch_relationship_category: regulation\ncompartment_description: Cytosol and nucleus\n[ca-loh1996] Calcineurin binds the transcription factor NFAT1 and reversibly regulates its activity (1996). https://pubmed.ncbi.nlm.nih.gov/8631904/ DOI: 10.1074/jbc.271.18.10884","model_system":"Murine T-cell experiments, inhibitor/chelation interventions and protein-binding assays","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [ca-loh1996] Calcineurin binds the transcription factor NFAT1 and reversibly regulates its activity (1996). https://pubmed.ncbi.nlm.nih.gov/8631904/ DOI: 10.1074/jbc.271.18.10884","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"3c083fa0-59c6-50e9-af42-678d0e3c1006","stable_key":"import-434e1e27-eb90-583a-956b-62472726ffba","title":"Calcium: mechanism-first literature curation (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"965c934d6b147f2b62f8d45ce6d7a87681a600bfe5c46a585b4704889afd3fc1","revision_id":"543ec48b-4f70-5197-9d76-f5a3c443664c","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}