{"id":"7a9abc64-0639-5d76-89b0-88f397dcdf90","stable_key":"18100170-a014-51c3-adeb-9dab4162b8cc:developmental-neutralization","predicate":"decreases_in_recorded_experiment","statement":"Neonatal thymulin immunoneutralization reduced later circulating LH/FSH in mice; engineered met-FTS protected gonadotropin output in thymus-deficient mice.","claim_class":"observational","status":"source_recorded","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"3b3cf117-9128-51be-ba93-f157ce2bfcb7","mechanism_event_label":"Neonatal thymulin immunoneutralization reduced later circulating LH/FSH in mice; engineered met-FTS protected gonadotropin output in thymus-deficient mice.","subject":{"id":"23819462-9bdf-5856-beac-68b3dca9cf85","slug":"thymulin","display_name":"Thymulin","entity_type_key":"peptide"},"object":{"id":"c4538cdc-bf29-53cb-ab89-18e089a97866","slug":"mouse-gonadotropin-output","display_name":"Mouse circulating LH and FSH output","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"3b3cf117-9128-51be-ba93-f157ce2bfcb7","stable_key":"18100170-a014-51c3-adeb-9dab4162b8cc:developmental-neutralization-event","event_type":"experimental_observation","label":"Neonatal thymulin immunoneutralization reduced later circulating LH/FSH in mice; engineered met-FTS protected gonadotropin output in thymus-deficient mice.","description":"There is also an experimental loss-of-function result: neonatal thymulin immunoneutralization in mice reduced later circulating LH/FSH, while engineered met-FTS delivery protected gonadotropin output in thymus-deficient mice. This supports a developmental endocrine role in those models; it is not equivalent to adult dietary zinc deficiency or an established human infertility mechanism. [2007 study](https://doi.org/10.1152/ajpendo.00085.2007)","status":"provisional","compartment":null,"participants":[{"entity":{"id":"23819462-9bdf-5856-beac-68b3dca9cf85","slug":"thymulin","display_name":"Thymulin","entity_type_key":"peptide"},"role":"tested factor","stoichiometry":null,"state_label":"Neonatal thymulin immunoneutralization","sequence_order":0,"notes":""},{"entity":{"id":"c4538cdc-bf29-53cb-ab89-18e089a97866","slug":"mouse-gonadotropin-output","display_name":"Mouse circulating LH and FSH output","entity_type_key":"cellular_process"},"role":"measured outcome","stoichiometry":null,"state_label":"decrease","sequence_order":1,"notes":""},{"entity":{"id":"9344cae9-4005-5e00-bb3f-9ac0d6feabc3","slug":"met-fts","display_name":"Engineered methionine-FTS analogue","entity_type_key":"peptide"},"role":"distinct rescue analogue","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary bibliographic record and abstract checked; full methods/figures not comprehensively reviewed.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_contrast","value_text":"{\"intervention\": \"Neonatal thymulin immunoneutralization\", \"comparator\": \"Non-neutralized control\", \"endpoint\": \"Neonatal thymulin immunoneutralization reduced later circulating LH/FSH in mice; engineered met-FTS protected gonadotropin output in thymus-deficient mice.\", \"effect_direction\": \"decrease\", \"combination\": \"single\", \"conditions\": []}","comparator":null,"unit":null,"notes":"Explicit extracted experimental comparison; source-derived draft.","entity":null},{"dimension":"experimental_model","value_text":"Neonatal immunoneutralization and engineered rescue in mouse models; separate from adult dietary depletion.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"interpretation_status","value_text":"Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Interpret only within the recorded preparation, exposure and comparator. The complete source passage retains qualifications; unspecified doses/timing have not been extracted here. No clinical efficacy, nutrient deficiency or unique molecular mediation is inferred.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Neonatal thymulin immunoneutralization reduced later circulating LH/FSH in mice; engineered met-FTS protected gonadotropin output in thymus-deficient mice.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Thymulin gene therapy prevents the reduction in circulating gonadotropins induced by thymulin deficiency in mice. | 2007 | DOI 10.1152/ajpendo.00085.2007 | PMID 17389714 | https://doi.org/10.1152/ajpendo.00085.2007","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"source_locator","value_text":"Reviewed reference lines 110-110; exact primary location described in quoted passage where extracted.","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"57698059-d190-509c-af23-48aabd9cd782","evidence_kind":"source_excerpt","locator":"Lines 110-110","start_line":110,"end_line":110,"excerpt":"There is also an experimental loss-of-function result: neonatal thymulin immunoneutralization in mice reduced later circulating LH/FSH, while engineered met-FTS delivery protected gonadotropin output in thymus-deficient mice. This supports a developmental endocrine role in those models; it is not equivalent to adult dietary zinc deficiency or an established human infertility mechanism. [2007 study](https://doi.org/10.1152/ajpendo.00085.2007)","model_system":"Neonatal immunoneutralization and engineered rescue in mouse models; separate from adult dietary depletion.","directness":"reported_statement","verification_status":"source_recorded","notes":"Exact excerpt of the retained AI-assisted reviewed reference; primary sources are cited in primary_references and access scope is retained. 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