{"id":"7a729211-dab5-5a06-a360-42949a9375e1","stable_key":"584c58f5-ab9f-53f3-97a9-55783db943b0:tryptophan-mtor-block-nam","predicate":"pharmacological_blockade_prevents_rescue","statement":"Rapamycin reduced mouse intestinal antimicrobial peptides, and nicotinamide did not rescue that reduction.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"97940291-4cc4-54e3-a3e1-34d61dc935dd","mechanism_event_label":"More precursor or downstream vitamin cannot replace every missing signal.","subject":{"id":"2bf56761-aaca-5d23-aadc-5d1f80178ec4","slug":"mouse-mtor","display_name":"Mouse mechanistic target of rapamycin / Mtor","entity_type_key":"protein"},"object":{"id":"eba9a619-26fc-540e-9a2d-6915c0b37e3a","slug":"mouse-trp-antimicrobial-peptides","display_name":"Mouse intestinal antimicrobial peptide expression in tryptophan experiments","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"97940291-4cc4-54e3-a3e1-34d61dc935dd","stable_key":"584c58f5-ab9f-53f3-97a9-55783db943b0:tryptophan-mtor-block-nam-event","event_type":"observed_relationship","label":"More precursor or downstream vitamin cannot replace every missing signal.","description":"Rapamycin reduced mouse intestinal antimicrobial peptides, and nicotinamide did not rescue that reduction.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"2bf56761-aaca-5d23-aadc-5d1f80178ec4","slug":"mouse-mtor","display_name":"Mouse mechanistic target of rapamycin / Mtor","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"eba9a619-26fc-540e-9a2d-6915c0b37e3a","slug":"mouse-trp-antimicrobial-peptides","display_name":"Mouse intestinal antimicrobial peptide expression in tryptophan experiments","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"769339cb-213b-559e-acc0-07ed00368b94","slug":"l-tryptophan","display_name":"L-Tryptophan","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"08c27a3f-552e-5c92-8688-321a9b64a0d6","slug":"nicotinamide","display_name":"Nicotinamide","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; 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