{"id":"7a39f2e5-0195-597a-9c72-ea7755d58108","stable_key":"00c24cfe-6189-5244-b81f-5d693e4e177d:chlorogenic_acid-iron-absorption","predicate":"reduces","statement":"CGA inhibited meal iron absorption, less strongly than the galloyl compounds tested.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"93a6b267-5bd0-5018-bbfc-df5c666a96d5","mechanism_event_label":"This interaction can reduce iron entering from a meal; it does not show iron being stripped from tissues.","subject":{"id":"705c7f84-5840-55e1-be69-383cc8793a06","slug":"chlorogenic-acid","display_name":"Chlorogenic acid / 5-O-caffeoylquinic acid","entity_type_key":"small_molecule"},"object":{"id":"4429d8ae-d732-5f5e-acc1-2c872e23da62","slug":"nonheme-iron-absorption","display_name":"Nonheme iron absorption","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"93a6b267-5bd0-5018-bbfc-df5c666a96d5","stable_key":"00c24cfe-6189-5244-b81f-5d693e4e177d:chlorogenic_acid-iron-absorption-event","event_type":"observed_intervention","label":"This interaction can reduce iron entering from a meal; it does not show iron being stripped from tissues.","description":"CGA inhibited meal iron absorption, less strongly than the galloyl compounds tested.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"705c7f84-5840-55e1-be69-383cc8793a06","slug":"chlorogenic-acid","display_name":"Chlorogenic acid / 5-O-caffeoylquinic acid","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"4429d8ae-d732-5f5e-acc1-2c872e23da62","slug":"nonheme-iron-absorption","display_name":"Nonheme iron absorption","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/chlorogenic_acid-research/2598894.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"dd211fea03837718abf36655d15cbb771700aeeb8d4f2086b90537561ee0b103\", \"start_char\": 0, \"end_char\": 2146, \"text_sha256\": \"dd211fea03837718abf36655d15cbb771700aeeb8d4f2086b90537561ee0b103\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human extrinsic-tag meal iron-absorption experiments","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Meals with chemically distinct phenolic compounds; CGA dose not specified in indexed abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The measured outcome is meal absorption, not systemic chelation or loss of cellular minerals. Effects of galloyl compounds, catechin and CGA were not interchangeable.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Chlorogenic acid research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"chlorogenic-acid","display_name":"Chlorogenic acid / 5-O-caffeoylquinic acid","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"This interaction can reduce iron entering from a meal; it does not show iron being stripped from tissues.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[chlorogenic_acid-p2598894] Iron absorption and phenolic compounds: importance of different phenolic structures. (1989). https://pubmed.ncbi.nlm.nih.gov/2598894/","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Gastrointestinal nonheme-iron absorption","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"336e9409-581e-54d5-8283-3a86a08f00da","evidence_kind":"source_excerpt","locator":"Lines 763-774","start_line":763,"end_line":774,"excerpt":"### chlorogenic_acid-iron-absorption\nCGA inhibited meal iron absorption, less strongly than the galloyl compounds tested.\nCondition category: normal\nnutrient_topic: Chlorogenic acid research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: This interaction can reduce iron entering from a meal; it does not show iron being stripped from tissues.\norganism: Human\ntissue_or_cell_type: Gastrointestinal nonheme-iron absorption\nexperimental_model: Human extrinsic-tag meal iron-absorption experiments\nlimitations: The measured outcome is meal absorption, not systemic chelation or loss of cellular minerals. Effects of galloyl compounds, catechin and CGA were not interchangeable.\nexposure: Meals with chemically distinct phenolic compounds; CGA dose not specified in indexed abstract\nevidence_span: {\"source_cache\": \"artifacts/chlorogenic_acid-research/2598894.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"dd211fea03837718abf36655d15cbb771700aeeb8d4f2086b90537561ee0b103\", \"start_char\": 0, \"end_char\": 2146, \"text_sha256\": \"dd211fea03837718abf36655d15cbb771700aeeb8d4f2086b90537561ee0b103\"}\n[chlorogenic_acid-p2598894] Iron absorption and phenolic compounds: importance of different phenolic structures. (1989). https://pubmed.ncbi.nlm.nih.gov/2598894/","model_system":"Human extrinsic-tag meal iron-absorption experiments","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [chlorogenic_acid-p2598894] Iron absorption and phenolic compounds: importance of different phenolic structures. (1989). https://pubmed.ncbi.nlm.nih.gov/2598894/","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"98a7cb8d-1d80-5cfe-9690-4068d21878e3","stable_key":"import-00c24cfe-6189-5244-b81f-5d693e4e177d","title":"Chlorogenic acid: metabolism, signaling and nutrient connections (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"dabd56b55fb10d82913b222343d9592d3baf61ef3cc81cf47f3e3e7537eb7992","revision_id":"340aee2f-52a6-56aa-99c1-0a24c534752a","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}