{"id":"7a18a95d-545d-5e15-9d03-6730e3b0536a","stable_key":"d96b230c-481b-535b-930c-04eb87ec7f02:s-allylcysteine-cisplatin-nrf2","predicate":"preserves_tested","statement":"SAC 25 mg/kg attenuated the cisplatin-associated reduction of renal cortical Nrf2.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"f313fd23-f096-51e7-99c2-2447fa8d5631","mechanism_event_label":"A drug-injury model showed preservation of a defense regulator.","subject":{"id":"8c2c295d-68b3-5e62-b1a7-00fcf915e3cc","slug":"s-allylcysteine","display_name":"S-allyl-L-cysteine / SAC","entity_type_key":"small_molecule"},"object":{"id":"27636f1d-fd51-5697-a8bb-6c827f4f8b40","slug":"rat-nfe2l2","display_name":"Rat Nrf2 / Nfe2l2","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"f313fd23-f096-51e7-99c2-2447fa8d5631","stable_key":"d96b230c-481b-535b-930c-04eb87ec7f02:s-allylcysteine-cisplatin-nrf2-event","event_type":"observed_relationship","label":"A drug-injury model showed preservation of a defense regulator.","description":"SAC 25 mg/kg attenuated the cisplatin-associated reduction of renal cortical Nrf2.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"8c2c295d-68b3-5e62-b1a7-00fcf915e3cc","slug":"s-allylcysteine","display_name":"S-allyl-L-cysteine / SAC","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"27636f1d-fd51-5697-a8bb-6c827f4f8b40","slug":"rat-nfe2l2","display_name":"Rat Nrf2 / Nfe2l2","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"bdb83796-78cf-5b54-9ca6-4dab19b33600","slug":"cisplatin","display_name":"Cisplatin","entity_type_key":"drug"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"acting_entity","value_text":"s-allylcysteine","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"dose","value_text":"SAC 25 mg/kg; 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