{"id":"79bcb0fc-900c-53bb-8d54-9adbbe3ea363","stable_key":"e0ea2d6a-7429-5e9f-b774-41e5e3288da3:ver-peroxyl-trapping","predicate":"traps","statement":"In azo-initiated methyl linoleate oxidation in solution, alpha-tocopherol interrupted the radical chain; the reported inhibition rate constant was 5.1 × 10^5 M^-1 s^-1 at 37 °C, with kinetics consistent with trapping two peroxyl radicals per molecule under those conditions.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"182a5fe2-0473-5e8d-8789-7bd01472392f","mechanism_event_label":"Vitamin E intercepted radicals that would otherwise continue oxidizing this fatty-acid ester.","subject":{"id":"40a6525a-76b8-576e-b73d-1e11aecf5f8d","slug":"alpha-tocopherol","display_name":"Alpha-tocopherol","entity_type_key":"small_molecule"},"object":{"id":"f9d22404-cc7a-5388-bc8f-3467df913793","slug":"lipid-peroxyl-radicals","display_name":"Lipid peroxyl radicals","entity_type_key":"chemical_species"},"evidence_count":1,"mechanism_event":{"id":"182a5fe2-0473-5e8d-8789-7bd01472392f","stable_key":"e0ea2d6a-7429-5e9f-b774-41e5e3288da3:ver-peroxyl-trapping-event","event_type":"biochemical_relationship","label":"Vitamin E intercepted radicals that would otherwise continue oxidizing this fatty-acid ester.","description":"In azo-initiated methyl linoleate oxidation in solution, alpha-tocopherol interrupted the radical chain; the reported inhibition rate constant was 5.1 × 10^5 M^-1 s^-1 at 37 °C, with kinetics consistent with trapping two peroxyl radicals per molecule under those conditions.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"201d7149-3030-592e-b364-fdd0ac516719","slug":"methyl-linoleate","display_name":"Methyl linoleate","entity_type_key":"small_molecule"},"role":"oxidizable substrate","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"40a6525a-76b8-576e-b73d-1e11aecf5f8d","slug":"alpha-tocopherol","display_name":"Alpha-tocopherol","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"f9d22404-cc7a-5388-bc8f-3467df913793","slug":"lipid-peroxyl-radicals","display_name":"Lipid peroxyl radicals","entity_type_key":"chemical_species"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"false","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_location","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Solution autoxidation kinetics","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Azo initiators; 37 °C.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Solution-specific kinetics and inferred stoichiometry, not a universal membrane rate.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin E research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-e","display_name":"Vitamin E","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Cell-free","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Vitamin E intercepted radicals that would otherwise continue oxidizing this fatty-acid ester.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[ver-niki1984] Inhibition of oxidation of methyl linoleate in solution by vitamin E and vitamin C. (1984). https://pubmed.ncbi.nlm.nih.gov/6706998/ DOI: 10.1016/s0021-9258(17)43026-2","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Organic solution","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"bf729341-50d1-5c94-bed2-7751ff25d85e","evidence_kind":"source_excerpt","locator":"Lines 480-492","start_line":480,"end_line":492,"excerpt":"### ver-peroxyl-trapping\nIn azo-initiated methyl linoleate oxidation in solution, alpha-tocopherol interrupted the radical chain; the reported inhibition rate constant was 5.1 × 10^5 M^-1 s^-1 at 37 °C, with kinetics consistent with trapping two peroxyl radicals per molecule under those conditions.\nCondition category: normal\nnutrient_topic: Vitamin E research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Vitamin E intercepted radicals that would otherwise continue oxidizing this fatty-acid ester.\norganism: Cell-free\ntissue_or_cell_type: Organic solution\nexperimental_model: Solution autoxidation kinetics\nlimitations: Solution-specific kinetics and inferred stoichiometry, not a universal membrane rate.\nexposure: Azo initiators; 37 °C.\ncross_nutrient: false\nevidence_location: Primary abstract\n[ver-niki1984] Inhibition of oxidation of methyl linoleate in solution by vitamin E and vitamin C. 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