{"id":"79b74090-4bc5-5e43-98d1-832a3185de83","stable_key":"1deb434a-3547-51a0-a038-87b1ce79ec38:vd-tlr-vdr","predicate":"activation-increases-expression","statement":"TLR activation increased VDR gene expression in human macrophages.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"6ae80d34-db8b-565f-af27-f31aea389b31","mechanism_event_label":"A pathogen-sensing signal increased part of the local vitamin D machinery.","subject":{"id":"d7edcae6-c1e9-5013-a99e-002acc62eef8","slug":"tlr2-tlr1","display_name":"TLR2-TLR1 receptor complex","entity_type_key":"protein_complex"},"object":{"id":"f0d510a4-812b-5f8a-889e-5b96a7e2a216","slug":"human-vdr-mrna","display_name":"Human VDR mRNA","entity_type_key":"rna"},"evidence_count":1,"mechanism_event":{"id":"6ae80d34-db8b-565f-af27-f31aea389b31","stable_key":"1deb434a-3547-51a0-a038-87b1ce79ec38:vd-tlr-vdr-event","event_type":"biochemical_relationship","label":"A pathogen-sensing signal increased part of the local vitamin D machinery.","description":"TLR activation increased VDR gene expression in human macrophages.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"6bd73bd2-1f0a-5caa-ba69-7ce1b75364bb","slug":"calcifediol","display_name":"Calcifediol / 25-hydroxyvitamin D3","entity_type_key":"small_molecule"},"role":"substrate","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"f5156c24-108f-5746-b114-ed764e79a3f4","slug":"calcitriol","display_name":"Calcitriol","entity_type_key":"small_molecule"},"role":"local-product","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"d725020b-bacc-5e90-b370-cda246025c91","slug":"vdr","display_name":"Vitamin D receptor / VDR","entity_type_key":"protein"},"role":"receptor","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"d7edcae6-c1e9-5013-a99e-002acc62eef8","slug":"tlr2-tlr1","display_name":"TLR2-TLR1 receptor complex","entity_type_key":"protein_complex"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"f0d510a4-812b-5f8a-889e-5b96a7e2a216","slug":"human-vdr-mrna","display_name":"Human VDR mRNA","entity_type_key":"rna"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"false","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human monocyte/macrophage TLR stimulation and intracellular mycobacterial assay","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"TLR activation in cultured human monocytes/macrophages.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Gene-expression result; does not mean any dietary D dose reproduces pathogen-triggered signaling.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin D2 and D3 research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-d","display_name":"Vitamin D2 and D3","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A pathogen-sensing signal increased part of the local vitamin D machinery.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[liu2006] Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. (2006). https://pubmed.ncbi.nlm.nih.gov/16497887/ DOI: 10.1126/science.1123933","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Human monocytes/macrophages","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"1f085c19-49e6-5810-8ea0-14fe46141007","evidence_kind":"source_excerpt","locator":"Lines 944-955","start_line":944,"end_line":955,"excerpt":"### vd-tlr-vdr\nTLR activation increased VDR gene expression in human macrophages.\nCondition category: normal\nnutrient_topic: Vitamin D2 and D3 research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A pathogen-sensing signal increased part of the local vitamin D machinery.\norganism: Homo sapiens\ntissue_or_cell_type: Human monocytes/macrophages\nexperimental_model: Human monocyte/macrophage TLR stimulation and intracellular mycobacterial assay\nlimitations: Gene-expression result; does not mean any dietary D dose reproduces pathogen-triggered signaling.\nexposure: TLR activation in cultured human monocytes/macrophages.\ncross_nutrient: false\n[liu2006] Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. (2006). https://pubmed.ncbi.nlm.nih.gov/16497887/ DOI: 10.1126/science.1123933","model_system":"Human monocyte/macrophage TLR stimulation and intracellular mycobacterial assay","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [liu2006] Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. (2006). https://pubmed.ncbi.nlm.nih.gov/16497887/ DOI: 10.1126/science.1123933","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"c95c763c-5b31-5b3f-a2f8-2dfe5ef0d3ca","stable_key":"import-1deb434a-3547-51a0-a038-87b1ce79ec38","title":"Vitamin D2 and D3: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"51004bf0d78db6146b8f198b0688a3cc7d4ea9822415a9c034f4c8790fb4e38b","revision_id":"d52ff207-a311-5f24-96f4-462838792db5","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}