{"id":"79b3f42b-0b70-5e0a-a0e2-1cc5256436ff","stable_key":"475ea55a-65e9-51c3-a539-738a6a8f683f:mangiferin-nrf2-nuclear","predicate":"increases","statement":"Mangiferin increased nuclear Nrf2 accumulation.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"1ba3ede1-1978-5635-9f4e-585304e93854","mechanism_event_label":"More of the regulator reached the nuclear compartment.","subject":{"id":"2cfc0bd9-b5cc-58ab-852a-7705f3d8d47f","slug":"mangiferin","display_name":"Mangiferin","entity_type_key":"small_molecule"},"object":{"id":"8d277132-f48b-5e60-89c3-e6260b756841","slug":"human-nrf2-nuclear-accumulation","display_name":"Human Nrf2 nuclear accumulation","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"1ba3ede1-1978-5635-9f4e-585304e93854","stable_key":"475ea55a-65e9-51c3-a539-738a6a8f683f:mangiferin-nrf2-nuclear-event","event_type":"biochemical_relationship","label":"More of the regulator reached the nuclear compartment.","description":"Mangiferin increased nuclear Nrf2 accumulation.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"2cfc0bd9-b5cc-58ab-852a-7705f3d8d47f","slug":"mangiferin","display_name":"Mangiferin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"8d277132-f48b-5e60-89c3-e6260b756841","slug":"human-nrf2-nuclear-accumulation","display_name":"Human Nrf2 nuclear accumulation","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/mangiferin-research/25380307.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"057a534a2074c49c824120d8e49fba7f4bde4d9d9b8bf15ef78f994083fdc8ea\", \"start_char\": 0, \"end_char\": 1636, \"text_sha256\": \"057a534a2074c49c824120d8e49fba7f4bde4d9d9b8bf15ef78f994083fdc8ea\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Isolated human cord-blood mononuclear cells","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Mangiferin and etoposide; concentration not specified in indexed abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Ex vivo DNA-damage and signaling assays; not evidence of clinical chemotherapy protection.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Mangiferin research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"mangiferin","display_name":"Mangiferin","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"More of the regulator reached the nuclear compartment.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[mangiferin-p25380307] Mangiferin activates the Nrf2-ARE pathway and reduces etoposide-induced DNA damage in human umbilical cord mononuclear blood cells. (2015). https://pubmed.ncbi.nlm.nih.gov/25380307/ DOI: 10.3109/13880209.2014.927890","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Cord-blood mononuclear cells","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"a4077a08-40cf-56e0-8abe-da461dc693ca","evidence_kind":"source_excerpt","locator":"Lines 562-573","start_line":562,"end_line":573,"excerpt":"### mangiferin-nrf2-nuclear\nMangiferin increased nuclear Nrf2 accumulation.\nCondition category: normal\nnutrient_topic: Mangiferin research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: More of the regulator reached the nuclear compartment.\norganism: Homo sapiens\ntissue_or_cell_type: Cord-blood mononuclear cells\nexperimental_model: Isolated human cord-blood mononuclear cells\nlimitations: Ex vivo DNA-damage and signaling assays; not evidence of clinical chemotherapy protection.\nexposure: Mangiferin and etoposide; concentration not specified in indexed abstract\nevidence_span: {\"source_cache\": \"artifacts/mangiferin-research/25380307.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"057a534a2074c49c824120d8e49fba7f4bde4d9d9b8bf15ef78f994083fdc8ea\", \"start_char\": 0, \"end_char\": 1636, \"text_sha256\": \"057a534a2074c49c824120d8e49fba7f4bde4d9d9b8bf15ef78f994083fdc8ea\"}\n[mangiferin-p25380307] Mangiferin activates the Nrf2-ARE pathway and reduces etoposide-induced DNA damage in human umbilical cord mononuclear blood cells. (2015). https://pubmed.ncbi.nlm.nih.gov/25380307/ DOI: 10.3109/13880209.2014.927890","model_system":"Isolated human cord-blood mononuclear cells","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [mangiferin-p25380307] Mangiferin activates the Nrf2-ARE pathway and reduces etoposide-induced DNA damage in human umbilical cord mononuclear blood cells. (2015). https://pubmed.ncbi.nlm.nih.gov/25380307/ DOI: 10.3109/13880209.2014.927890","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"267f942a-695a-5b62-a858-f71c06321ff5","stable_key":"import-475ea55a-65e9-51c3-a539-738a6a8f683f","title":"Mangiferin: metabolism, signaling and nutrient connections (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"295cb3a13742b3caeed19347ffcbc7863f5372d983da1625a942428919b4dc98","revision_id":"d9c2ee89-ff22-5e86-9d7f-7cb7e17f9ed2","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}