{"id":"793549cd-4870-55e6-bc46-e57d19594753","stable_key":"a8bedee0-a740-5bbb-921e-bfd144c7b68c:astaxanthin-hydroxy-fatty-acid","predicate":"uncertain_between_group_effect","statement":"After 8 mg/day for three months, hydroxy-fatty-acid biomarkers decreased within the astaxanthin arm, but the reported between-group 15-HFA comparison was P=0.056.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"b73ff201-2e31-52b6-b732-f773a84c3c5c","mechanism_event_label":"A within-group improvement did not establish a statistically significant treatment difference.","subject":{"id":"1bf8b9c0-9c38-5c8a-b5da-f00b0eeca36f","slug":"astaxanthin","display_name":"Astaxanthin","entity_type_key":"small_molecule"},"object":{"id":"8ee0432f-d6a7-55ff-a6d5-5b212eb7ece3","slug":"human-astaxanthin-hydroxy-fatty-acids","display_name":"Human plasma hydroxy-fatty-acid oxidation biomarkers after astaxanthin","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"b73ff201-2e31-52b6-b732-f773a84c3c5c","stable_key":"a8bedee0-a740-5bbb-921e-bfd144c7b68c:astaxanthin-hydroxy-fatty-acid-event","event_type":"observed_relationship","label":"A within-group improvement did not establish a statistically significant treatment difference.","description":"After 8 mg/day for three months, hydroxy-fatty-acid biomarkers decreased within the astaxanthin arm, but the reported between-group 15-HFA comparison was P=0.056.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"1bf8b9c0-9c38-5c8a-b5da-f00b0eeca36f","slug":"astaxanthin","display_name":"Astaxanthin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"8ee0432f-d6a7-55ff-a6d5-5b212eb7ece3","slug":"human-astaxanthin-hydroxy-fatty-acids","display_name":"Human plasma hydroxy-fatty-acid oxidation biomarkers after astaxanthin","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human randomized supplementation study in men.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Preserve the comparator analysis; do not convert a borderline between-group result into proven benefit.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Astaxanthin collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"astaxanthin","display_name":"Astaxanthin","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A within-group improvement did not establish a statistically significant treatment difference.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Effects of astaxanthin supplementation on lipid peroxidation. · 2007 · https://pubmed.ncbi.nlm.nih.gov/17685090/ · DOI 10.1024/0300-9831.77.1.3","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"04448789-f989-5f90-865b-3192aae3dab6","evidence_kind":"source_excerpt","locator":"Lines 422-428","start_line":422,"end_line":428,"excerpt":"## astaxanthin-hydroxy-fatty-acid\nA within-group improvement did not establish a statistically significant treatment difference.\nAfter 8 mg/day for three months, hydroxy-fatty-acid biomarkers decreased within the astaxanthin arm, but the reported between-group 15-HFA comparison was P=0.056.\nModel: Human randomized supplementation study in men.\nLimitations: Preserve the comparator analysis; do not convert a borderline between-group result into proven benefit.\nEvidence access: Primary abstract\nEffects of astaxanthin supplementation on lipid peroxidation. · 2007 · https://pubmed.ncbi.nlm.nih.gov/17685090/ · DOI 10.1024/0300-9831.77.1.3","model_system":"Human randomized supplementation study in men.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"4fd91ea6-78b4-5bfe-93e3-686fbef9f678","stable_key":"import-a8bedee0-a740-5bbb-921e-bfd144c7b68c","title":"Astaxanthin: transport, membrane chemistry, signaling and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. 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