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it does not imply Ca replaces Mg at the ThDP site.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Magnesium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"magnesium","display_name":"Magnesium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Sus scrofa","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Calcium regulation and magnesium support can act together in the enzyme preparation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[panov-1996-ogdh] Independent modulation of the activity of alpha-ketoglutarate dehydrogenase complex by Ca2+ and Mg2+ (1996). https://pubmed.ncbi.nlm.nih.gov/8555212/ DOI: 10.1021/bi952101t","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Purified heart mitochondrial enzyme","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"4b704c73-c85d-503f-95f5-608cd542fbd8","evidence_kind":"source_excerpt","locator":"Lines 687-697","start_line":687,"end_line":697,"excerpt":"### mg-ogdh-calcium-additivity\nCa and Mg stimulation of purified pig-heart KGDHC was additive over the tested lower free-ion ranges.\nCondition category: normal\nnutrient_topic: Magnesium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Calcium regulation and magnesium support can act together in the enzyme preparation.\norganism: Sus scrofa\ntissue_or_cell_type: Purified heart mitochondrial enzyme\nexperimental_model: Purified pig-heart KGDHC, controlled free divalent-ion and cofactor concentrations.\nlimitations: Additivity depended on concentration; it does not imply Ca replaces Mg at the ThDP site.\ncross_nutrient: Calcium and magnesium effects on a thiamine-dependent enzyme were additive under specified assay conditions.\n[panov-1996-ogdh] Independent modulation of the activity of alpha-ketoglutarate dehydrogenase complex by Ca2+ and Mg2+ (1996). https://pubmed.ncbi.nlm.nih.gov/8555212/ DOI: 10.1021/bi952101t","model_system":"Purified pig-heart KGDHC, controlled free divalent-ion and cofactor concentrations.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. 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