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Recombinant sheep enzyme, not human enzyme in a tissue.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Aspirin research collection; topical membership is not evidence of a direct clinical effect, and aspirin is recorded separately from salicylate, the metabolite it becomes.","comparator":null,"unit":null,"notes":"","entity":{"slug":"aspirin","display_name":"Aspirin / acetylsalicylic acid","entity_type_key":"drug"}},{"dimension":"organism","value_text":"Sheep and mouse enzyme","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The acetyl group works by being in the way, not by removing something the enzyme needed.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[asa-p2108169] The aspirin and heme-binding sites of ovine and murine prostaglandin endoperoxide synthases. 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Recombinant sheep enzyme, not human enzyme in a tissue.\nexposure: Serine 530 replaced with alanine, compared with the native enzyme against aspirin and reversible inhibitors\nevidence_span: {\"source_cache\": \"artifacts/aspirin-research/2108169.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"c7b11508521a3854b432f3836de6e92ba9863c8edb244d747bb1c37634c0bb50\", \"start_char\": 0, \"end_char\": 2076, \"text_sha256\": \"c7b11508521a3854b432f3836de6e92ba9863c8edb244d747bb1c37634c0bb50\"}\n[asa-p2108169] The aspirin and heme-binding sites of ovine and murine prostaglandin endoperoxide synthases. 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