{"id":"787e5f0a-4da7-5bf2-b9db-22954b43c614","stable_key":"649e861b-265a-5912-bc36-3a73e53ef892:l-serine-sfxn1-rescue-boundary","predicate":"supports_heme_and_2_oxoglutarate_metabolism","statement":"The study attributed SFXN1-dependent complex III support to heme and 2-oxoglutarate metabolism rather than to its one-carbon-metabolism role alone.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"5756e87b-fd03-50c4-a699-3942316f791c","mechanism_event_label":"Two effects of the same transporter can run through different downstream routes.","subject":{"id":"8d8fb144-4bb5-5b97-8a22-207c2e9c5206","slug":"sfxn1","display_name":"Human sideroflexin 1 / SFXN1","entity_type_key":"protein"},"object":{"id":"d2608bf7-03c0-511c-8374-7aed036b4ed1","slug":"human-sfxn1-complex-iii-support","display_name":"Heme and 2-oxoglutarate support of SFXN1-dependent complex III function","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"5756e87b-fd03-50c4-a699-3942316f791c","stable_key":"649e861b-265a-5912-bc36-3a73e53ef892:l-serine-sfxn1-rescue-boundary-event","event_type":"observed_relationship","label":"Two effects of the same transporter can run through different downstream routes.","description":"The study attributed SFXN1-dependent complex III support to heme and 2-oxoglutarate metabolism rather than to its one-carbon-metabolism role alone.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"8d8fb144-4bb5-5b97-8a22-207c2e9c5206","slug":"sfxn1","display_name":"Human sideroflexin 1 / SFXN1","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"d2608bf7-03c0-511c-8374-7aed036b4ed1","slug":"human-sfxn1-complex-iii-support","display_name":"Heme and 2-oxoglutarate support of SFXN1-dependent complex III function","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"c882cd0b-9d83-5b07-bd1c-fe4d45657dcb","slug":"l-serine","display_name":"L-Serine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"628ddc2d-e4d9-59c7-ae76-0c0cab80a6b1","slug":"2-oxoglutarate","display_name":"2-Oxoglutarate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human cell metabolic and respiratory-chain experiments.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"This does not reduce all SFXN1 phenotypes to one folate bottleneck.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Serine collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"l-serine","display_name":"L-Serine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Two effects of the same transporter can run through different downstream routes.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"The mitochondrial carrier SFXN1 is critical for complex III integrity and cellular metabolism. · 2021 · https://pubmed.ncbi.nlm.nih.gov/33730581/ · DOI 10.1016/j.celrep.2021.108869","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"e1716a46-a344-5085-ab8f-c344ab909c21","evidence_kind":"source_excerpt","locator":"Lines 166-172","start_line":166,"end_line":172,"excerpt":"## l-serine-sfxn1-rescue-boundary\nTwo effects of the same transporter can run through different downstream routes.\nThe study attributed SFXN1-dependent complex III support to heme and 2-oxoglutarate metabolism rather than to its one-carbon-metabolism role alone.\nModel: Human cell metabolic and respiratory-chain experiments.\nLimitations: This does not reduce all SFXN1 phenotypes to one folate bottleneck.\nEvidence access: Primary abstract\nThe mitochondrial carrier SFXN1 is critical for complex III integrity and cellular metabolism. · 2021 · https://pubmed.ncbi.nlm.nih.gov/33730581/ · DOI 10.1016/j.celrep.2021.108869","model_system":"Human cell metabolic and respiratory-chain experiments.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"70bcf57a-36bb-563f-9073-2d616e5f155a","stable_key":"import-649e861b-265a-5912-bc36-3a73e53ef892","title":"L-Serine: synthesis, one-carbon metabolism, lipids and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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