{"id":"787b38bc-e30e-5760-90e0-41a5fab788c6","stable_key":"220adaab-10d8-5c4e-a3f5-a48700ea794d:agmatine-sulfate-arginine-pain-interaction","predicate":"attenuates_in_model","statement":"L-arginine at 600 mg/kg intraperitoneally attenuated agmatine-associated antinociception in the mouse acetic-acid test.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"74370c91-44fc-50a8-a102-73a01580cfb9","mechanism_event_label":"A precursor-related nutrient changed the response in a pharmacological animal experiment.","subject":{"id":"eeca3c9e-7749-5677-b7bd-37fe8f7c228d","slug":"arginine","display_name":"L-Arginine","entity_type_key":"small_molecule"},"object":{"id":"52f4f6e6-2732-5f55-be82-0a0abcc9eb08","slug":"mouse-agmatine-antinociception","display_name":"Mouse agmatine-associated antinociception","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"74370c91-44fc-50a8-a102-73a01580cfb9","stable_key":"220adaab-10d8-5c4e-a3f5-a48700ea794d:agmatine-sulfate-arginine-pain-interaction-event","event_type":"observed_relationship","label":"A precursor-related nutrient changed the response in a pharmacological animal experiment.","description":"L-arginine at 600 mg/kg intraperitoneally attenuated agmatine-associated antinociception in the mouse acetic-acid test.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"eeca3c9e-7749-5677-b7bd-37fe8f7c228d","slug":"arginine","display_name":"L-Arginine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"52f4f6e6-2732-5f55-be82-0a0abcc9eb08","slug":"mouse-agmatine-antinociception","display_name":"Mouse agmatine-associated antinociception","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"ae2dddf4-ce04-57e3-8a06-7ed9fdc24554","slug":"agmatine-sulfate","display_name":"Agmatine Sulfate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"e2f83eb4-99ed-5050-87d3-3e4701d05c1a","slug":"agmatine","display_name":"Agmatine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Mouse chemical-pain assays; high-dose injected arginine.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"This does not prove that normal dietary arginine negates an oral agmatine supplement or identify one exclusive target.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Agmatine Sulfate collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"agmatine-sulfate","display_name":"Agmatine Sulfate","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A precursor-related nutrient changed the response in a pharmacological animal experiment.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Mechanisms involved in the antinociception caused by agmatine in mice. · 2005 · https://pubmed.ncbi.nlm.nih.gov/15857629/ · DOI 10.1016/j.neuropharm.2005.01.012","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"020b09da-bb08-58ca-bff9-c574e10abad3","evidence_kind":"source_excerpt","locator":"Lines 428-434","start_line":428,"end_line":434,"excerpt":"## agmatine-sulfate-arginine-pain-interaction\nA precursor-related nutrient changed the response in a pharmacological animal experiment.\nL-arginine at 600 mg/kg intraperitoneally attenuated agmatine-associated antinociception in the mouse acetic-acid test.\nModel: Mouse chemical-pain assays; high-dose injected arginine.\nLimitations: This does not prove that normal dietary arginine negates an oral agmatine supplement or identify one exclusive target.\nEvidence access: Primary abstract\nMechanisms involved in the antinociception caused by agmatine in mice. · 2005 · https://pubmed.ncbi.nlm.nih.gov/15857629/ · DOI 10.1016/j.neuropharm.2005.01.012","model_system":"Mouse chemical-pain assays; high-dose injected arginine.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"e0426971-7d13-51c9-8354-6547b664f1cf","stable_key":"import-220adaab-10d8-5c4e-a3f5-a48700ea794d","title":"Agmatine Sulfate: transport, guanidino metabolism, ion channels and cross-nutrient mechanisms (2026-09-20)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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