{"id":"785fa6fd-ce84-50e6-ac08-c8134f46f24c","stable_key":"220adaab-10d8-5c4e-a3f5-a48700ea794d:agmatine-sulfate-antizyme-frameshift","predicate":"promotes","statement":"Agmatine promoted an antizyme-mRNA frameshift producing full-length antizyme; anti-antizyme antibody or antizyme inhibitor suppressed associated inhibitory activity.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"380f0e9a-c798-588c-a8cc-a329c75a3b5e","mechanism_event_label":"It can influence production of a regulator of polyamine metabolism.","subject":{"id":"e2f83eb4-99ed-5050-87d3-3e4701d05c1a","slug":"agmatine","display_name":"Agmatine","entity_type_key":"small_molecule"},"object":{"id":"289be60f-556a-5ff2-83f6-7434c393dcce","slug":"antizyme-frameshift-agmatine-1998","display_name":"Agmatine-dependent antizyme translational frameshift in the 1998 experiments","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"380f0e9a-c798-588c-a8cc-a329c75a3b5e","stable_key":"220adaab-10d8-5c4e-a3f5-a48700ea794d:agmatine-sulfate-antizyme-frameshift-event","event_type":"observed_relationship","label":"It can influence production of a regulator of polyamine metabolism.","description":"Agmatine promoted an antizyme-mRNA frameshift producing full-length antizyme; 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anti-antizyme antibody or antizyme inhibitor suppressed associated inhibitory activity.\nModel: Cell and translation assays; exact construct and cell species not resolved in accessed abstract.\nLimitations: This is not assigned to a human isoform without checking the complete preparation.\nEvidence access: Primary abstract\nAgmatine suppresses proliferation by frameshift induction of antizyme and attenuation of cellular polyamine levels. · 1998 · https://pubmed.ncbi.nlm.nih.gov/9624108/ · DOI 10.1074/jbc.273.25.15313","model_system":"Cell and translation assays; exact construct and cell species not resolved in accessed abstract.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"e0426971-7d13-51c9-8354-6547b664f1cf","stable_key":"import-220adaab-10d8-5c4e-a3f5-a48700ea794d","title":"Agmatine Sulfate: transport, guanidino metabolism, ion channels and cross-nutrient mechanisms (2026-09-20)","document_type":"imported_text","citation_label":"AI-assisted research curation; 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