{"id":"7837754e-5844-5582-b0d9-b05ccb1e9070","stable_key":"ee4227e5-80d7-55e9-ada7-3c5a16f93ac9:cla-cytokines","predicate":"increases_secretion","statement":"CLA treatment increased IL-6 and IL-8 secretion from the human adipose culture systems.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"dd20b9e8-08b4-5979-900e-b09cbf0d2992","mechanism_event_label":"The response could signal to neighboring cells.","subject":{"id":"4405f918-c17d-5365-b873-1678989f8ac1","slug":"cla-trans10-cis12","display_name":"trans-10,cis-12 conjugated linoleic acid","entity_type_key":"small_molecule"},"object":{"id":"364992bb-f7d7-5e4d-967b-b6646faafd2b","slug":"human-adipocyte-cla-inflammatory-output","display_name":"Human adipocyte CLA-associated cytokine output","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"dd20b9e8-08b4-5979-900e-b09cbf0d2992","stable_key":"ee4227e5-80d7-55e9-ada7-3c5a16f93ac9:cla-cytokines-event","event_type":"observed_relationship","label":"The response could signal to neighboring cells.","description":"CLA treatment increased IL-6 and IL-8 secretion from the human adipose culture systems.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"4405f918-c17d-5365-b873-1678989f8ac1","slug":"cla-trans10-cis12","display_name":"trans-10,cis-12 conjugated linoleic acid","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"364992bb-f7d7-5e4d-967b-b6646faafd2b","slug":"human-adipocyte-cla-inflammatory-output","display_name":"Human adipocyte CLA-associated cytokine output","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"ef8f8807-395d-5dc6-9693-70e90f41b268","slug":"il6","display_name":"IL6","entity_type_key":"cytokine"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"5dd031e8-9ede-5db7-a4e1-961de31f0b49","slug":"cxcl8","display_name":"Human interleukin-8 / CXCL8","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human adipocytes, stromal-vascular cells and adipose explants.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Culture concentrations and cell mixtures limit extrapolation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"CLA collection; isomer, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"conjugated-linoleic-acid","display_name":"Conjugated linoleic acid / CLA isomer family","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"The response could signal to neighboring cells.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Conjugated linoleic acid promotes human adipocyte insulin resistance through NFkappaB-dependent cytokine production. · 2005 · https://pubmed.ncbi.nlm.nih.gov/16155293/ · DOI 10.1074/jbc.M508159200","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"63c8bb2b-4e7c-58ea-9373-9027e22637f1","evidence_kind":"source_excerpt","locator":"Lines 134-140","start_line":134,"end_line":140,"excerpt":"## cla-cytokines\nThe response could signal to neighboring cells.\nCLA treatment increased IL-6 and IL-8 secretion from the human adipose culture systems.\nModel: Human adipocytes, stromal-vascular cells and adipose explants.\nLimitations: Culture concentrations and cell mixtures limit extrapolation.\nEvidence access: Primary abstract\nConjugated linoleic acid promotes human adipocyte insulin resistance through NFkappaB-dependent cytokine production. · 2005 · https://pubmed.ncbi.nlm.nih.gov/16155293/ · DOI 10.1074/jbc.M508159200","model_system":"Human adipocytes, stromal-vascular cells and adipose explants.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"45cfa6e3-2e7d-57c1-8c35-65302b7b71db","stable_key":"import-ee4227e5-80d7-55e9-ada7-3c5a16f93ac9","title":"Conjugated linoleic acid: isomers, signaling, nutrient interactions and discovery (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. 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