{"id":"7825ddba-eee4-5ee4-b129-9479a1a047ba","stable_key":"1ff3a29f-ef80-5bff-9300-30b98c60b90d:strontium-rabbit-ip3-difference","predicate":"acts_without_required_ip3","statement":"Unlike calcium in the same experimental program, strontium-associated osteoclast apoptosis was independent of inositol 1,4,5-trisphosphate action.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"2f77f057-483e-5c9d-b6be-a5deb9100f29","mechanism_event_label":"Similar ions need not use identical intracellular messengers.","subject":{"id":"97607549-3a37-544e-b6e6-266887f7c35f","slug":"strontium-ion","display_name":"Strontium ion / Sr2+","entity_type_key":"ion"},"object":{"id":"35aba475-0d0e-5063-8ccc-a93f3e4638e2","slug":"rabbit-mature-osteoclast-apoptosis","display_name":"Apoptosis of mature rabbit osteoclasts","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"2f77f057-483e-5c9d-b6be-a5deb9100f29","stable_key":"1ff3a29f-ef80-5bff-9300-30b98c60b90d:strontium-rabbit-ip3-difference-event","event_type":"observed_relationship","label":"Similar ions need not use identical intracellular messengers.","description":"Unlike calcium in the same experimental program, strontium-associated osteoclast apoptosis was independent of inositol 1,4,5-trisphosphate action.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"97607549-3a37-544e-b6e6-266887f7c35f","slug":"strontium-ion","display_name":"Strontium ion / Sr2+","entity_type_key":"ion"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"35aba475-0d0e-5063-8ccc-a93f3e4638e2","slug":"rabbit-mature-osteoclast-apoptosis","display_name":"Apoptosis of mature rabbit osteoclasts","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"2ca2864b-1ef0-54e4-8397-1dbe7207a0d2","slug":"strontium","display_name":"Strontium","entity_type_key":"nutrient_element"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"e359bc15-e675-5d83-b0fe-1d70814e130b","slug":"calcium-ion","display_name":"Calcium ion","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"7005bbc2-d4b5-5903-b776-94dd2288d35f","slug":"ip3","display_name":"IP3","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Rabbit osteoclast pathway perturbations.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Absence of IP3 dependence here is not absence of calcium signaling in every strontium response.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Strontium collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"strontium","display_name":"Strontium","entity_type_key":"nutrient_element"}},{"dimension":"plain_language","value_text":"Similar ions need not use identical intracellular messengers.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"The calcium-sensing receptor is involved in strontium ranelate-induced osteoclast apoptosis. New insights into the associated signaling pathways. · 2009 · https://pubmed.ncbi.nlm.nih.gov/18927086/ · DOI 10.1074/jbc.M801668200","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"4fcab074-805a-5edd-826c-48385213f1ec","evidence_kind":"source_excerpt","locator":"Lines 230-236","start_line":230,"end_line":236,"excerpt":"## strontium-rabbit-ip3-difference\nSimilar ions need not use identical intracellular messengers.\nUnlike calcium in the same experimental program, strontium-associated osteoclast apoptosis was independent of inositol 1,4,5-trisphosphate action.\nModel: Rabbit osteoclast pathway perturbations.\nLimitations: Absence of IP3 dependence here is not absence of calcium signaling in every strontium response.\nEvidence access: Primary abstract\nThe calcium-sensing receptor is involved in strontium ranelate-induced osteoclast apoptosis. New insights into the associated signaling pathways. · 2009 · https://pubmed.ncbi.nlm.nih.gov/18927086/ · DOI 10.1074/jbc.M801668200","model_system":"Rabbit osteoclast pathway perturbations.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"43ef0fe7-eb6c-5346-8381-f7694733b4dc","stable_key":"import-1ff3a29f-ef80-5bff-9300-30b98c60b90d","title":"Strontium: calcium interactions, cellular mechanisms and mineralization (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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