{"id":"77c8ddf8-124f-5fee-a1c7-a72b64e87236","stable_key":"d96b230c-481b-535b-930c-04eb87ec7f02:s-allylcysteine-srebp","predicate":"reduces_tested_abundance_of","statement":"SAC reduced SREBP-1 levels and expression of lipogenic targets including ACC and FAS in HepG2 cells.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"557819fa-a4f5-566f-9362-e2eacfed96f1","mechanism_event_label":"The lipid-production program changed as well as kinase activity.","subject":{"id":"8c2c295d-68b3-5e62-b1a7-00fcf915e3cc","slug":"s-allylcysteine","display_name":"S-allyl-L-cysteine / SAC","entity_type_key":"small_molecule"},"object":{"id":"278d2aa8-ed70-58ab-8650-3d9b32f725b5","slug":"srebf1","display_name":"Sterol regulatory element-binding protein 1 / SREBP-1","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"557819fa-a4f5-566f-9362-e2eacfed96f1","stable_key":"d96b230c-481b-535b-930c-04eb87ec7f02:s-allylcysteine-srebp-event","event_type":"observed_relationship","label":"The lipid-production program changed as well as kinase activity.","description":"SAC reduced SREBP-1 levels and expression of lipogenic targets including ACC and FAS in HepG2 cells.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"8c2c295d-68b3-5e62-b1a7-00fcf915e3cc","slug":"s-allylcysteine","display_name":"S-allyl-L-cysteine / SAC","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"278d2aa8-ed70-58ab-8650-3d9b32f725b5","slug":"srebf1","display_name":"Sterol regulatory element-binding protein 1 / SREBP-1","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"c56cf3ba-9e4a-5357-8645-969b8c4d6792","slug":"fasn","display_name":"Human fatty acid synthase / FASN","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"acting_entity","value_text":"s-allylcysteine","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"dose","value_text":"Not specified in accessed abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"Not specified in accessed abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_comparison","value_text":"SAC addition; 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