{"id":"77c4cac2-cfbf-563b-a897-73eb2b6544cc","stable_key":"aad5a443-96e9-52eb-963a-812e90f9f896:lycopene-paste-absorption","predicate":"increased","statement":"Tomato paste produced a 3.8-fold higher chylomicron lycopene AUC than fresh tomatoes with matched lycopene and corn oil.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"a3029afc-3cc1-5ce4-9a53-a7bb80be33fa","mechanism_event_label":"Food structure matters even when the amount of lycopene is the same.","subject":{"id":"7ad842ec-c311-52bc-94de-8919c6e04bbc","slug":"tomato-paste-intervention","display_name":"Study-specific tomato paste food intervention","entity_type_key":"chemical_species"},"object":{"id":"279fd193-6e16-5495-8e20-afc051d71985","slug":"lycopene-postprandial-trl-response","display_name":"Postprandial lycopene response in triglyceride-rich lipoproteins","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"a3029afc-3cc1-5ce4-9a53-a7bb80be33fa","stable_key":"aad5a443-96e9-52eb-963a-812e90f9f896:lycopene-paste-absorption-event","event_type":"biochemical_relationship","label":"Food structure matters even when the amount of lycopene is the same.","description":"Tomato paste produced a 3.8-fold higher chylomicron lycopene AUC than fresh tomatoes with matched lycopene and corn oil.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"0b16e027-7a68-55ae-8e33-eae8b5cd1e9e","slug":"lycopene","display_name":"Lycopene","entity_type_key":"small_molecule"},"role":"measured_carotenoid","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"7ad842ec-c311-52bc-94de-8919c6e04bbc","slug":"tomato-paste-intervention","display_name":"Study-specific tomato paste food intervention","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"279fd193-6e16-5495-8e20-afc051d71985","slug":"lycopene-postprandial-trl-response","display_name":"Postprandial lycopene response in triglyceride-rich lipoproteins","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/lycopene-research/9209178.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"9e44d803f52bf022b12d9bbffbe5e2832be523d37ccfbcf2187296c5fb89200f\", \"start_char\": 0, \"end_char\": 985, \"text_sha256\": \"9e44d803f52bf022b12d9bbffbe5e2832be523d37ccfbcf2187296c5fb89200f\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human single-meal bioavailability comparison","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"23 mg lycopene from fresh tomato or paste with 15 g corn oil","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Both meals contained oil; does not isolate an oil effect or establish all heating improves availability.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Lycopene research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"lycopene","display_name":"Lycopene","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Food structure matters even when the amount of lycopene is the same.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[lycopene-p9209178] Lycopene is more bioavailable from tomato paste than from fresh tomatoes. 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