{"id":"77a7faaa-eb18-5aef-83c5-0519baa624d3","stable_key":"8c094dea-83bb-53f1-8ad6-2780b4f131eb:minus-lariciresinol-inhibits-other-hepadnaviruses","predicate":"reduces","statement":"(-)-Lariciresinol dose-dependently inhibited other animal hepadnaviruses, including woodchuck hepatitis virus and duck hepatitis B virus.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"1656d286-810f-5cf5-b0d1-9d78d4cbdd66","mechanism_event_label":"(-)-Lariciresinol dose-dependently inhibited other animal hepadnaviruses, including woodchuck hepatitis virus and duck hepatitis B virus.","subject":{"id":"bf9b95e9-f2d1-52bc-b68b-68f541085aeb","slug":"minus-lariciresinol","display_name":"(-)-Lariciresinol","entity_type_key":"small_molecule"},"object":{"id":"31233dda-b6b9-595e-a17d-ffca6e3cae7c","slug":"other-hepadnavirus-replication","display_name":"Woodchuck hepatitis virus and duck hepatitis B virus replication","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"1656d286-810f-5cf5-b0d1-9d78d4cbdd66","stable_key":"8c094dea-83bb-53f1-8ad6-2780b4f131eb:minus-lariciresinol-inhibits-other-hepadnaviruses-event","event_type":"observed_relationship","label":"(-)-Lariciresinol dose-dependently inhibited other animal hepadnaviruses, including woodchuck hepatitis virus and duck hepatitis B virus.","description":"(-)-Lariciresinol dose-dependently inhibited other animal hepadnaviruses, including woodchuck hepatitis virus and duck hepatitis B virus.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"bf9b95e9-f2d1-52bc-b68b-68f541085aeb","slug":"minus-lariciresinol","display_name":"(-)-Lariciresinol","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"31233dda-b6b9-595e-a17d-ffca6e3cae7c","slug":"other-hepadnavirus-replication","display_name":"Woodchuck hepatitis virus and duck hepatitis B virus replication","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"c9b0f8e4-4823-5067-a352-61b4c37cd11b","slug":"hnf1a","display_name":"Human hepatocyte nuclear factor 1 alpha / HNF1A","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"duration","value_text":"Not stated here","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Cell systems carrying woodchuck hepatitis virus and duck hepatitis B virus","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"(-)-Lariciresinol, dose-dependent","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Activity across three hepadnaviruses is consistent with a host target rather than a viral enzyme, but the abstract does not give the concentrations or the size of the reduction for each virus.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"organism","value_text":"Cell systems carrying woodchuck hepatitis virus and duck hepatitis B virus","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"(-)-Lariciresinol dose-dependently inhibited other animal hepadnaviruses, including woodchuck hepatitis virus and duck hepatitis B virus.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"(-)-Lariciresinol Isolated from the Roots of Isatis indigotica Fortune ex Lindl. Inhibits Hepatitis B Virus by Regulating Viral Transcription. (2022). https://pubmed.ncbi.nlm.nih.gov/35630700/ DOI: 10.3390/molecules27103223","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"In vitro","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Hepadnaviral replication across species","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"ac807d8a-c1cc-57e0-8ba1-c6f015c1c510","evidence_kind":"source_excerpt","locator":"Lines 22-31","start_line":22,"end_line":31,"excerpt":"## minus-lariciresinol-inhibits-other-hepadnaviruses\n(-)-Lariciresinol dose-dependently inhibited other animal hepadnaviruses, including woodchuck hepatitis virus and duck hepatitis B virus.\nModel/species: Cell systems carrying woodchuck hepatitis virus and duck hepatitis B virus\nTissue/system: Hepadnaviral replication across species\nExposure: (-)-Lariciresinol, dose-dependent\nRoute: In vitro\nDuration: Not stated here\nLimits: Activity across three hepadnaviruses is consistent with a host target rather than a viral enzyme, but the abstract does not give the concentrations or the size of the reduction for each virus.\nPrimary reference: (-)-Lariciresinol Isolated from the Roots of Isatis indigotica Fortune ex Lindl. Inhibits Hepatitis B Virus by Regulating Viral Transcription. (2022). https://pubmed.ncbi.nlm.nih.gov/35630700/ DOI: 10.3390/molecules27103223\nAccess: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","model_system":"","directness":"reported_statement","verification_status":"source_derived_draft","notes":"","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"9ca4f4ed-6090-5e7d-9327-81eae8924fcb","stable_key":"import-8c094dea-83bb-53f1-8ad6-2780b4f131eb","title":"(-)-Lariciresinol and hepatocyte nuclear factor 1 alpha: the host-factor step (2026-09-22)","document_type":"imported_text","citation_label":"Original AI-assisted curation of twelve primary studies, every abstract read and all DOIs cross-checked against live PubMed metadata. Mechanism edges only, with no conclusion or claim of benefit recorded. Three author clusters account for eight of the twelve and carry shared laboratory keys. Study-specific concentrations, negative findings and limitations retained. Not publisher full text.","file_path":"","sha256":"f226f699d178d9ae63fdf6e5d80ae0077b7e5bfda4e0683b836fc057a7ac1eca","revision_id":"4503344a-a294-5dd8-bff9-c2966f2464cb","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}