{"id":"7755cb9e-7eae-55db-b453-f41d1bba046e","stable_key":"6660bba2-4fa0-590a-bf52-9803a24bea9f:setshift-null","predicate":"no_detected_change_in_recorded_experiment","statement":"Attentional set shifting did not significantly improve in the sixty-man modafinil trial.","claim_class":"observational","status":"source_recorded","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"6bdb1541-fc7a-5001-ba8c-889e377e5742","mechanism_event_label":"Attentional set shifting did not significantly improve in the sixty-man modafinil trial.","subject":{"id":"624e6a4b-f96d-5d12-8206-30d1e1715c26","slug":"modafinil","display_name":"Modafinil","entity_type_key":"drug"},"object":{"id":"d3247114-837e-5544-a5f3-8e8734528c82","slug":"human-attentional-set-shifting","display_name":"Human attentional set-shifting task performance","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"6bdb1541-fc7a-5001-ba8c-889e377e5742","stable_key":"6660bba2-4fa0-590a-bf52-9803a24bea9f:setshift-null-event","event_type":"experimental_observation","label":"Attentional set shifting did not significantly improve in the sixty-man modafinil trial.","description":"In a 60-man randomized trial, modafinil improved selected memory, planning and inhibitory-control measures, while slowing responses on some tasks. Several other measures—including attentional set shifting—did not significantly improve. Objective benefit and null results belong together. [Turner et al.](https://pubmed.ncbi.nlm.nih.gov/12417966/)","status":"provisional","compartment":null,"participants":[{"entity":{"id":"624e6a4b-f96d-5d12-8206-30d1e1715c26","slug":"modafinil","display_name":"Modafinil","entity_type_key":"drug"},"role":"tested factor","stoichiometry":null,"state_label":"Modafinil","sequence_order":0,"notes":""},{"entity":{"id":"d3247114-837e-5544-a5f3-8e8734528c82","slug":"human-attentional-set-shifting","display_name":"Human attentional set-shifting task performance","entity_type_key":"cellular_process"},"role":"measured outcome","stoichiometry":null,"state_label":"no_detected_change","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary indexed abstract checked; full methods and figures not comprehensively reviewed.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_contrast","value_text":"{\"intervention\": \"Modafinil\", \"comparator\": \"Placebo\", \"endpoint\": \"Attentional set shifting did not significantly improve in the sixty-man modafinil trial.\", \"effect_direction\": \"no_detected_change\", \"combination\": \"single\", \"conditions\": []}","comparator":null,"unit":null,"notes":"Explicit extracted experimental comparison; source-derived draft.","entity":null},{"dimension":"experimental_model","value_text":"Human randomized cognitive trial; preserved negative endpoint.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"interpretation_status","value_text":"Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Interpret only within the recorded preparation, exposure and comparator. The complete source passage retains qualifications; unspecified doses/timing have not been extracted here. No clinical efficacy, nutrient deficiency or unique molecular mediation is inferred.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Attentional set shifting did not significantly improve in the sixty-man modafinil trial.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Cognitive enhancing effects of modafinil in healthy volunteers. | 2003 | DOI 10.1007/s00213-002-1250-8 | PMID 12417966 | https://pubmed.ncbi.nlm.nih.gov/12417966/","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"source_locator","value_text":"Reviewed reference lines 152-152; exact primary location described in quoted passage where extracted.","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"6ffc2a6e-8797-5bf1-be47-4e31fd815825","evidence_kind":"source_excerpt","locator":"Lines 152-152","start_line":152,"end_line":152,"excerpt":"In a 60-man randomized trial, modafinil improved selected memory, planning and inhibitory-control measures, while slowing responses on some tasks. Several other measures—including attentional set shifting—did not significantly improve. Objective benefit and null results belong together. [Turner et al.](https://pubmed.ncbi.nlm.nih.gov/12417966/)","model_system":"Human randomized cognitive trial; preserved negative endpoint.","directness":"reported_statement","verification_status":"source_recorded","notes":"Exact excerpt of the retained AI-assisted reviewed reference; primary sources are cited in primary_references and access scope is retained. Not a verbatim quotation from a primary paper.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"17a64928-eaa2-5117-ba4f-52dcbdf9cc9e","stable_key":"import-6660bba2-4fa0-590a-bf52-9803a24bea9f","title":"Modafinil: detailed mechanisms of action (reviewed 3 October 2026)","document_type":"imported_text","citation_label":"Original AI-assisted review of primary studies and, where relevant, official regulatory records. Access level is retained per claim. 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