{"id":"774da418-013c-5062-a4b9-63b1ccd17e92","stable_key":"1acdb1e8-2159-5c7f-b39f-0153ff8024ae:taurine-microbial-protection","predicate":"feeding_enhances","statement":"Supplying exogenous taurine enhanced microbiota-mediated resistance to subsequent enteric infection in mice.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"a17b961e-aa61-5f83-adb8-d17a38523301","mechanism_event_label":"In another setting, feeding microbes taurine improved pathogen resistance.","subject":{"id":"e423cd36-f183-522b-a5e4-5f9ef50eee7e","slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"},"object":{"id":"30ac623d-314a-5e08-9fb3-8bae16f31784","slug":"mouse-taurine-colonization-resistance","display_name":"Taurine-associated microbial colonization resistance in mice","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"a17b961e-aa61-5f83-adb8-d17a38523301","stable_key":"1acdb1e8-2159-5c7f-b39f-0153ff8024ae:taurine-microbial-protection-event","event_type":"observed_relationship","label":"In another setting, feeding microbes taurine improved pathogen resistance.","description":"Supplying exogenous taurine enhanced microbiota-mediated resistance to subsequent enteric infection in mice.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"e423cd36-f183-522b-a5e4-5f9ef50eee7e","slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"30ac623d-314a-5e08-9fb3-8bae16f31784","slug":"mouse-taurine-colonization-resistance","display_name":"Taurine-associated microbial colonization resistance in mice","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"70cc3ced-8adc-5e76-9750-e1415683455b","slug":"hydrogen-sulfide","display_name":"Hydrogen sulfide / H2S","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Mouse infection, microbiota and taurine intervention experiments.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"This outcome differs from Il10-null colitis; neither result is a universal rule about intestinal taurine.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Taurine collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"In another setting, feeding microbes taurine improved pathogen resistance.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Infection trains the host for microbiota-enhanced resistance to pathogens. · 2021 · https://pubmed.ncbi.nlm.nih.gov/33453153/ · DOI 10.1016/j.cell.2020.12.011","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"652f07ab-2fb5-5e70-baaa-a146350d3f63","evidence_kind":"source_excerpt","locator":"Lines 345-351","start_line":345,"end_line":351,"excerpt":"## taurine-microbial-protection\nIn another setting, feeding microbes taurine improved pathogen resistance.\nSupplying exogenous taurine enhanced microbiota-mediated resistance to subsequent enteric infection in mice.\nModel: Mouse infection, microbiota and taurine intervention experiments.\nLimitations: This outcome differs from Il10-null colitis; neither result is a universal rule about intestinal taurine.\nEvidence access: Primary abstract\nInfection trains the host for microbiota-enhanced resistance to pathogens. · 2021 · https://pubmed.ncbi.nlm.nih.gov/33453153/ · DOI 10.1016/j.cell.2020.12.011","model_system":"Mouse infection, microbiota and taurine intervention experiments.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dc8d9ab8-fdf9-5107-877c-336cf8005097","stable_key":"import-1acdb1e8-2159-5c7f-b39f-0153ff8024ae","title":"Taurine: synthesis, transport, mitochondrial decoding and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. 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