{"id":"77156487-7f67-557b-ba79-ed5861472c1f","stable_key":"dc8975b1-95ff-5d9b-be17-a1c04610cca7:mo-cpmp-early-limit","predicate":"early_replacement_did_not_prevent_all","statement":"Despite fosdenopterin within ten minutes of birth, the infant developed early seizures and retained motor impairment; seizures resolved and cognition was relatively spared.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"7043b1e5-e5c0-54e6-ab2e-dda65e5e3149","mechanism_event_label":"Even rapid replacement may not undo injury that began before birth.","subject":{"id":"f0e47ca8-1073-5e0a-b77f-c881660ee6d0","slug":"cpmp","display_name":"Cyclic pyranopterin monophosphate / cPMP","entity_type_key":"small_molecule"},"object":{"id":"1889a337-09ce-56fa-97eb-e67086e3c53c","slug":"mocd-neurological-outcome","display_name":"Neurological outcome in molybdenum cofactor deficiency","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"7043b1e5-e5c0-54e6-ab2e-dda65e5e3149","stable_key":"dc8975b1-95ff-5d9b-be17-a1c04610cca7:mo-cpmp-early-limit-event","event_type":"observed_intervention","label":"Even rapid replacement may not undo injury that began before birth.","description":"Despite fosdenopterin within ten minutes of birth, the infant developed early seizures and retained motor impairment; seizures resolved and cognition was relatively spared.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"f0e47ca8-1073-5e0a-b77f-c881660ee6d0","slug":"cpmp","display_name":"Cyclic pyranopterin monophosphate / cPMP","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"1889a337-09ce-56fa-97eb-e67086e3c53c","slug":"mocd-neurological-outcome","display_name":"Neurological outcome in molybdenum cofactor deficiency","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/molybdenum-research/40429556.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"25a9bcc9dc74084f82ec89ca2850ea25ee8ae156c6650d69ccd460d66d02e1d1\", \"start_char\": 0, \"end_char\": 1369, \"text_sha256\": \"25a9bcc9dc74084f82ec89ca2850ea25ee8ae156c6650d69ccd460d66d02e1d1\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Prenatally diagnosed MoCD-A single case with immediate neonatal fosdenopterin","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Delivery at 32 weeks 6 days; drug within 10 minutes of birth","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"One case. Residual injury suggests prenatal disease, but does not prove efficacy or safety of fetal treatment.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Molybdenum research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"molybdenum","display_name":"Molybdenum","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Even rapid replacement may not undo injury that began before birth.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[mo-p40429556] Early Neonatal Fosdenopterin Treatment for Molybdenum Cofactor Deficiency Type A: New Insights into Its Natural History and Potential Role for Fetal Therapy. (2025). https://pubmed.ncbi.nlm.nih.gov/40429556/ DOI: 10.3390/jcm14103561","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Fetal/neonatal brain and follow-up to 24 months","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"b8cbbc30-8b46-5129-a323-056d63f2b2db","evidence_kind":"source_excerpt","locator":"Lines 1210-1221","start_line":1210,"end_line":1221,"excerpt":"### mo-cpmp-early-limit\nDespite fosdenopterin within ten minutes of birth, the infant developed early seizures and retained motor impairment; seizures resolved and cognition was relatively spared.\nCondition category: machinery_impairment\nnutrient_topic: Molybdenum research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Even rapid replacement may not undo injury that began before birth.\norganism: Homo sapiens\ntissue_or_cell_type: Fetal/neonatal brain and follow-up to 24 months\nexperimental_model: Prenatally diagnosed MoCD-A single case with immediate neonatal fosdenopterin\nlimitations: One case. Residual injury suggests prenatal disease, but does not prove efficacy or safety of fetal treatment.\nexposure: Delivery at 32 weeks 6 days; drug within 10 minutes of birth\nevidence_span: {\"source_cache\": \"artifacts/molybdenum-research/40429556.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"25a9bcc9dc74084f82ec89ca2850ea25ee8ae156c6650d69ccd460d66d02e1d1\", \"start_char\": 0, \"end_char\": 1369, \"text_sha256\": \"25a9bcc9dc74084f82ec89ca2850ea25ee8ae156c6650d69ccd460d66d02e1d1\"}\n[mo-p40429556] Early Neonatal Fosdenopterin Treatment for Molybdenum Cofactor Deficiency Type A: New Insights into Its Natural History and Potential Role for Fetal Therapy. 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(2025). https://pubmed.ncbi.nlm.nih.gov/40429556/ DOI: 10.3390/jcm14103561","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"1aa6da60-8284-5252-8dd9-ac2250d5ced5","stable_key":"import-dc8975b1-95ff-5d9b-be17-a1c04610cca7","title":"Molybdenum: cofactor assembly, sulfur metabolism and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"143147eb9ac7fe750bdd33bb50d7773bc0cd49cc94faf219aebce3c3d760dd8f","revision_id":"90c2239d-290b-5e16-815a-f94d30569ebd","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}