{"id":"76ee36f2-a58f-5cc5-a6be-75d5b791d1ca","stable_key":"35ec55a7-323c-5c28-979e-3bdafe9d5769:blueberry-pk","predicate":"context_dependent_observation","statement":"After the tested blueberry meal, parent anthocyanins peaked earlier than several glucuronides and phenolic products.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"f256878e-233b-54c5-aaac-654f95b0dcdd","mechanism_event_label":"After the tested blueberry meal, parent anthocyanins peaked earlier than several glucuronides and phenolic products.","subject":{"id":"8ba6e5a5-f7a0-5cab-a623-dd65cd18afaf","slug":"wild-blueberry-powder","display_name":"Wild blueberry powder preparation","entity_type_key":"botanical"},"object":{"id":"00395c15-8064-5b04-bf78-c8b2a89ab0c8","slug":"human-c3g-parent-metabolite-time-profiles","display_name":"Human serum C3G and metabolite concentration-time profiles","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"f256878e-233b-54c5-aaac-654f95b0dcdd","stable_key":"35ec55a7-323c-5c28-979e-3bdafe9d5769:blueberry-pk-event","event_type":"experimental_observation","label":"After the tested blueberry meal, parent anthocyanins peaked earlier than several glucuronides and phenolic products.","description":"**Whole-blueberry kinetics differ from a purified bolus.** In a meal-associated crossover study using 25 g freeze-dried wild-blueberry powder, parent anthocyanins peaked around two hours; individual glucuronide profiles peaked later, and phenolic acids ranged from early to late peaks. The reported anthocyanin bioavailability estimate was 1.1% under that study's method. It cannot replace the differently defined isotope-recovery measure or establish a class-wide absolute absorption percentage. [Zhong et al., 2017](https://pubmed.ncbi.nlm.nih.gov/28887907/).","status":"provisional","compartment":null,"participants":[{"entity":{"id":"8ba6e5a5-f7a0-5cab-a623-dd65cd18afaf","slug":"wild-blueberry-powder","display_name":"Wild blueberry powder preparation","entity_type_key":"botanical"},"role":"tested factor","stoichiometry":null,"state_label":"as reported","sequence_order":0,"notes":""},{"entity":{"id":"00395c15-8064-5b04-bf78-c8b2a89ab0c8","slug":"human-c3g-parent-metabolite-time-profiles","display_name":"Human serum C3G and metabolite concentration-time profiles","entity_type_key":"cellular_process"},"role":"measured outcome","stoichiometry":null,"state_label":"mixed","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary indexed abstract reviewed; full methods, figures, exact doses or endpoint-specific species assignments may remain unextracted.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human crossover meal study, 25 g freeze-dried wild-blueberry powder, 24-hour plasma sampling.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"interpretation_status","value_text":"Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Interpret only within the recorded preparation, exposure and comparator. The complete source passage retains qualifications; unspecified doses/timing have not been extracted here. No clinical efficacy, nutrient deficiency or unique molecular mediation is inferred.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"After the tested blueberry meal, parent anthocyanins peaked earlier than several glucuronides and phenolic products.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Characterization of Wild Blueberry Polyphenols Bioavailability and Kinetic Profile in Plasma over 24-h Period in Human Subjects. | 2017 | DOI 10.1002/mnfr.201700405 | PMID 28887907 | https://pubmed.ncbi.nlm.nih.gov/28887907/ | https://doi.org/10.1002/mnfr.201700405","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"source_locator","value_text":"Reviewed reference lines 32-32; exact primary location described in quoted passage where extracted.","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"4a213595-0a6c-5d13-b5d2-46792867ba6f","evidence_kind":"source_excerpt","locator":"Lines 32-32","start_line":32,"end_line":32,"excerpt":"**Whole-blueberry kinetics differ from a purified bolus.** In a meal-associated crossover study using 25 g freeze-dried wild-blueberry powder, parent anthocyanins peaked around two hours; individual glucuronide profiles peaked later, and phenolic acids ranged from early to late peaks. The reported anthocyanin bioavailability estimate was 1.1% under that study's method. It cannot replace the differently defined isotope-recovery measure or establish a class-wide absolute absorption percentage. [Zhong et al., 2017](https://pubmed.ncbi.nlm.nih.gov/28887907/).","model_system":"Human crossover meal study, 25 g freeze-dried wild-blueberry powder, 24-hour plasma sampling.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact excerpt of the retained AI-assisted reviewed reference; primary sources are cited in primary_references and access scope is retained. Not a verbatim quotation from a primary paper.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"b08e7f7d-4d34-56d7-a185-2124f8d72b3c","stable_key":"import-35ec55a7-323c-5c28-979e-3bdafe9d5769","title":"Anthocyanins: detailed mechanisms of action (reviewed 4 October 2026)","document_type":"imported_text","citation_label":"Original AI-assisted review of primary studies and, where relevant, official regulatory records. Access level is retained per claim. Corrections, null results and unresolved questions remain explicit. Not publisher full text or independent replication.","file_path":"","sha256":"7cff1a47fbd9c625412b84162b1c823004b4162b7c009f9a11d5807fb8e04ef9","revision_id":"1bd4fa42-bfeb-5148-8250-fc363d8c1de0","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}