{"id":"768e6533-3241-5a65-885f-552ee6d20206","stable_key":"c3df3634-4c3a-5099-a5d9-e4f6344c1084:cat1-lysine-transport","predicate":"transports","statement":"Human CAT1 transports L-lysine across the plasma membrane.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"e9d60a9e-a3b6-54ef-88e8-1749a55d7760","mechanism_event_label":"CAT1 moves free lysine across cell membranes.","subject":{"id":"d7fa43de-bc79-5059-b3ca-1a233156f4d1","slug":"slc7a1","display_name":"CAT1 / SLC7A1","entity_type_key":"protein"},"object":{"id":"5fff6664-209e-5c35-b88e-ac15c1c5fbc0","slug":"l-lysine","display_name":"L-Lysine","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"e9d60a9e-a3b6-54ef-88e8-1749a55d7760","stable_key":"c3df3634-4c3a-5099-a5d9-e4f6344c1084:cat1-lysine-transport-event","event_type":"biochemical_relationship","label":"CAT1 moves free lysine across cell membranes.","description":"Human CAT1 transports L-lysine across the plasma membrane.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"d7fa43de-bc79-5059-b3ca-1a233156f4d1","slug":"slc7a1","display_name":"CAT1 / SLC7A1","entity_type_key":"protein"},"role":"transporter","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"5fff6664-209e-5c35-b88e-ac15c1c5fbc0","slug":"l-lysine","display_name":"L-Lysine","entity_type_key":"small_molecule"},"role":"transported_substrate","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"Human CAT1 expressed in Xenopus oocytes","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Transporter expression assay; the relative contribution varies by tissue.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"CAT1 moves free lysine across cell membranes.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[furesz2002] Lysine uptake by cloned hCAT-2B: comparison with hCAT-1 and with trophoblast surface membranes. (2002). https://pubmed.ncbi.nlm.nih.gov/12202949/ DOI: 10.1007/s00232-002-1001-0","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Plasma membrane; compared with placental trophoblast membranes","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"transport_effect","value_text":"depends","comparator":null,"unit":null,"notes":"The record names the membrane lysine crosses and not which way it crosses it.","entity":null},{"dimension":"transport_pool","value_text":"the cytosol across the plasma membrane","comparator":null,"unit":null,"notes":"The record names the membrane lysine crosses and not which way it crosses it.","entity":null}],"evidence":[{"id":"5eaf6d0c-a0da-5fab-a9d6-db1e006e80c0","evidence_kind":"source_excerpt","locator":"Lines 14-22","start_line":14,"end_line":22,"excerpt":"### cat1-lysine-transport\nHuman CAT1 transports L-lysine across the plasma membrane.\nPlain language: CAT1 moves free lysine across cell membranes.\nCondition category: normal\norganism: Homo sapiens\ntissue_or_cell_type: Plasma membrane; compared with placental trophoblast membranes\nexperimental_model: Human CAT1 expressed in Xenopus oocytes\nlimitations: Transporter expression assay; the relative contribution varies by tissue.\n[furesz2002] Lysine uptake by cloned hCAT-2B: comparison with hCAT-1 and with trophoblast surface membranes. (2002). https://pubmed.ncbi.nlm.nih.gov/12202949/ DOI: 10.1007/s00232-002-1001-0","model_system":"Human CAT1 expressed in Xenopus oocytes","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact quote from the accompanying curation document, not from publisher text. Original study references: [furesz2002] Lysine uptake by cloned hCAT-2B: comparison with hCAT-1 and with trophoblast surface membranes. (2002). https://pubmed.ncbi.nlm.nih.gov/12202949/ DOI: 10.1007/s00232-002-1001-0","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"7633bde7-dcc9-5086-91c6-a45eb96857f3","stable_key":"import-c3df3634-4c3a-5099-a5d9-e4f6344c1084","title":"L-Lysine: mechanism-first literature curation (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"93998d47c21525409ba82f1c82ededf2893dff15fbe61c7deffc175b0e298e97","revision_id":"3897e31f-6624-59e1-a053-8a81b7361632","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}